Literature DB >> 27423479

Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.

Dong-Jun Fu1, Sai-Yang Zhang1, Ying-Chao Liu1, Li Zhang1, Jun-Ju Liu1, Jian Song1, Ruo-Han Zhao1, Feng Li1, Hui-Hui Sun1, Hong-Min Liu1, Yan-Bing Zhang1.   

Abstract

A series of novel dithiocarbamate-chalcone derivates were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell lines (EC-109, SK-N-SH and MGC-803). Majority of the synthesized compounds exhibited moderate to potent activity against all the cancer cell lines assayed. Particularly, compounds II2 and II5 exhibited the excellent growth inhibition against SK-N-SH with IC50 values of 2.03μM and 2.46μM, respectively. Further mechanism studies revealed that compound II2 could obviously inhibit the proliferation of SK-N-SH cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antiproliferative activity; Apoptosis; Chalcone; Dithiocarbamate

Mesh：

Substances：

Year:  2016        PMID： 27423479     DOI： 10.1016/j.bmcl.2016.07.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

1.  Molecular diversity of phenothiazines: design and synthesis of phenothiazine-dithiocarbamate hybrids as potential cell cycle blockers.

Authors:  Dong-Jun Fu; Ruo-Han Zhao; Jia-Huan Li; Jia-Jia Yang; Ruo-Wang Mao; Bo-Wen Wu; Ping Li; Xiao-Lin Zi; Qing-Qing Zhang; Hui-Jie Cai; Sai-Yang Zhang; Yan-Bing Zhang; Hong-Min Liu
Journal:  Mol Divers       Date:  2017-08-07       Impact factor: 2.943

Review 2.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

3.  Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

Authors:  Dong-Jun Fu; Li Zhang; Jian Song; Ruo-Wang Mao; Ruo-Han Zhao; Ying-Chao Liu; Yu-Hui Hou; Jia-Huan Li; Jia-Jia Yang; Cheng-Yun Jin; Ping Li; Xiao-Lin Zi; Hong-Min Liu; Sai-Yang Zhang; Yan-Bing Zhang
Journal:  Eur J Med Chem       Date:  2016-12-14       Impact factor: 6.514

4.  Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors.

Authors:  Shewei Guo; Yingwei Zhen; Mengguo Guo; Longzhou Zhang; Guosheng Zhou
Journal:  Invest New Drugs       Date:  2018-07-18       Impact factor: 3.850

5.  Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.

Authors:  Dong-Jun Fu; Jian Song; Yu-Hui Hou; Ruo-Han Zhao; Jia-Huan Li; Ruo-Wang Mao; Jia-Jia Yang; Ping Li; Xiao-Lin Zi; Zhong-Hua Li; Qing-Qing Zhang; Fei-Yan Wang; Sai-Yang Zhang; Yan-Bing Zhang; Hong-Min Liu
Journal:  Eur J Med Chem       Date:  2017-07-08       Impact factor: 6.514

6.  2-Hydroxychalcone as a Potent Compound and Photosensitizer Against Dermatophyte Biofilms.

Authors:  Níura Madalena Bila; Caroline Barcelos Costa-Orlandi; Carolina Orlando Vaso; Jean Lucas Carvalho Bonatti; Letícia Ribeiro de Assis; Luís Octavio Regasini; Carla Raquel Fontana; Ana Marisa Fusco-Almeida; Maria José Soares Mendes-Giannini
Journal:  Front Cell Infect Microbiol       Date:  2021-05-13       Impact factor: 5.293

7.  Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.

Authors:  Xuan Zhao; WenLiang Dong; YuanDi Gao; Dong-Shoo Shin; Qing Ye; Le Su; Fan Jiang; BaoXiang Zhao; JunYing Miao
Journal:  Sci Rep       Date:  2017-06-20       Impact factor: 4.379

8.  Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors.

Authors:  Dong-Jun Fu; Ji-Feng Liu; Ruo-Han Zhao; Jia-Huan Li; Sai-Yang Zhang; Yan-Bing Zhang
Journal:  Molecules       Date:  2017-09-05       Impact factor: 4.411

9.  Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer.

Authors:  Jun-Xia Zhang; Jiao-Mei Guo; Ting-Ting Zhang; Hong-Jun Lin; Nai-Song Qi; Zhen-Guo Li; Ji-Chun Zhou; Zhen-Zhong Zhang
Journal:  Molecules       Date:  2018-05-28       Impact factor: 4.411

10.  Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site.

Authors:  Dong-Jun Fu; Ling Fu; Ying-Chao Liu; Jun-Wei Wang; Yu-Qing Wang; Bing-Kai Han; Xiao-Rui Li; Chuang Zhang; Feng Li; Jian Song; Bing Zhao; Ruo-Wang Mao; Ruo-Han Zhao; Sai-Yang Zhang; Li Zhang; Yan-Bing Zhang; Hong-Min Liu
Journal:  Sci Rep       Date:  2017-10-06       Impact factor: 4.379
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