Literature DB >> 27422336

Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines.

Germán F Giri1, Mauro Danielli2, Raúl A Marinelli2, Rolando A Spanevello1.   

Abstract

Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50 values of cisplatin, a frequently administered chemotherapy drug.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cancer cell lines; Cytotoxic activity; Hepatocarcinoma; Levoglucosenone; Michael addition

Mesh：

Substances：

Year:  2016        PMID： 27422336     DOI： 10.1016/j.bmcl.2016.07.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit.

Authors:  Husam Qanash; Reham Yahya; Marwah M Bakri; Abdulrahman S Bazaid; Sultan Qanash; Abdullah F Shater; Abdelghany T M
Journal:  Sci Rep       Date:  2022-04-08       Impact factor: 4.379

Review 2.  Levoglucosenone: Bio-Based Platform for Drug Discovery.

Authors:  Jason E Camp; Ben W Greatrex
Journal:  Front Chem       Date:  2022-05-31       Impact factor: 5.545

3.  Antineoplastic activity of products derived from cellulose-containing materials: levoglucosenone and structurally-related derivatives as new alternatives for breast cancer treatment.

Authors:  Damian Ignacio Delbart; German Francisco Giri; Agostina Cammarata; Melisan Denise Pan; Lizeth Ariza Bareño; Natalia Loreley Amigo; Andrés Bechis; Alejandra Graciela Suarez; Rolando Ángel Spanevello; Marcela Solange Villaverde; Laura Beatriz Todaro; Alejandro Jorge Urtreger
Journal:  Invest New Drugs       Date:  2021-09-03       Impact factor: 3.850

4.  Effects of nest type and sex on blood saccharide profiles in Humboldt penguins (Spheniscus humboldti): Implications for habitat conservation.

Authors:  David J Schaeffer; Jeffrey M Levengood; Michael J Adkesson
Journal:  PLoS One       Date:  2020-05-21       Impact factor: 3.240
  4 in total

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