Literature DB >> 27422087

Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces.

Shyam B Mehta1, John F Carpenter1, Theodore W Randolph2.   

Abstract

In this study, we investigated the effect of ionic strength (1.25-231 mM) on viscoelastic interfacial gels formed by a monoclonal antibody at silicone oil-water interfaces, and the formation of subvisible particles due to rupture of these gels. Rates of gel formation and their elastic moduli did not vary significantly with ionic strength. Likewise, during gel rupture no significant effects of ionic strength were observed on particle formation and aggregation as detected by microflow imaging, resonance mass measurement, and size exclusion chromatography. Subvisible particles formed by mechanical rupturing of the gels agglomerated over time, even during quiescent incubation, due to the colloidal instability of the particles.
Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  IgG antibody; colloid; gels; monoclonal antibody; protein formulation; proteins; rheology; salts/salt selection; stability

Mesh：

Substances：

Year:  2016        PMID： 27422087     DOI： 10.1016/j.xphs.2016.06.010

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  11 in total

1.  Influence of Fatty Acid Modification on Uptake of Lovastatin-Loaded Reconstituted High Density Lipoprotein by Foam Cells.

Authors:  Yun Yang; Ji Wang; Hongliang He; Wenli Zhang; Yuansheng Zhang; Jianping Liu
Journal:  Pharm Res       Date:  2018-05-07       Impact factor: 4.200

2.  Protein Adsorption and Layer Formation at the Stainless Steel-Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody.

Authors:  Cavan K Kalonia; Frank Heinrich; Joseph E Curtis; Sid Raman; Maria A Miller; Steven D Hudson
Journal:  Mol Pharm       Date:  2018-02-20       Impact factor: 4.939

3.  Biodistribution and Pharmacokinetic Evaluations of a Novel Taxoid DHA-SBT-1214 in an Oil-in-Water Nanoemulsion Formulation in Naïve and Tumor-Bearing Mice.

Authors:  Gulzar Ahmad; Florence Gattacecca; Rana El Sadda; Galina Botchkina; Iwao Ojima; James Egan; Mansoor Amiji
Journal:  Pharm Res       Date:  2018-03-08       Impact factor: 4.200

4.  Reversion of Multidrug Resistance by Co-Encapsulation of Doxorubicin and Metformin in Poly(lactide-co-glycolide)-d-α-tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles.

Authors:  Vahid Shafiei-Irannejad; Nasser Samadi; Roya Salehi; Bahman Yousefi; Mahdi Rahimi; Abolfazl Akbarzadeh; Nosratollah Zarghami
Journal:  Pharm Res       Date:  2018-04-18       Impact factor: 4.200

5.  Anti-GPC3 Antibody Tagged Cationic Switchable Lipid-Based Nanoparticles for the Co-Delivery of Anti-miRNA27a And Sorafenib in Liver Cancers.

Authors:  Zhengfeng Wang; Kun Zhao; Yingxuan Zhang; Xinxin Duan; Yongfu Zhao
Journal:  Pharm Res       Date:  2019-08-08       Impact factor: 4.200

6.  Biocorona formation contributes to silver nanoparticle induced endoplasmic reticulum stress.

Authors:  Indushekhar Persaud; Jonathan H Shannahan; Achyut J Raghavendra; Nasser B Alsaleh; Ramakrishna Podila; Jared M Brown
Journal:  Ecotoxicol Environ Saf       Date:  2018-12-04       Impact factor: 6.291

7.  Hollow Microparticles as a Superior Delivery System over Solid Microparticles for the Encapsulation of Peptides.

Authors:  Sharad Kharel; Archana Gautam; Andreas Dickescheid; Say Chye Joachim Loo
Journal:  Pharm Res       Date:  2018-08-02       Impact factor: 4.200

8.  Hyaluronic Acid Layer-By-Layer (LbL) Nanoparticles for Synergistic Chemo-Phototherapy.

Authors:  Juan Zhao; Zhuoya Wan; Chuchu Zhou; Qin Yang; Jianxia Dong; Xu Song; Tao Gong
Journal:  Pharm Res       Date:  2018-08-24       Impact factor: 4.200

9.  Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses.

Authors:  Neha N Pardeshi; Chen Zhou; Theodore W Randolph; John F Carpenter
Journal:  J Pharm Sci       Date:  2018-03-27       Impact factor: 3.534

10.  A Mechanistic Understanding of Monoclonal Antibody Interfacial Protection by Hydrolytically Degraded Polysorbate 20 and 80 under IV Bag Conditions.

Authors:  Aadithya Kannan; Jamie Giddings; Shrenik Mehta; Tiffany Lin; Anthony Tomlinson; Kyle Ritchie; Ian Shieh; Miguel Saggu; Nidhi Doshi
Journal:  Pharm Res       Date:  2022-03-11       Impact factor: 4.200
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.