Guy Shalom1,2, Jacob Dreiher3,4, Arnon Cohen3,4. 1. Department of Dermatology and Venereology, Soroka Medical Center, Beer-Sheva, Israel. guyshallom1234@hotmail.com. 2. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. guyshallom1234@hotmail.com. 3. Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. 4. Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
Abstract
BACKGROUND: Psoriasis is a chronic inflammatory skin disorder that is associated with the metabolic syndrome and its components. An association between obstructive sleep apnea (OSA) and the metabolic syndrome was previously observed. OBJECTIVES: To investigate the association between psoriasis and OSA in a comprehensive community-based database. MATERIALS AND METHODS: The study was performed utilizing the medical database of Clalit Health Services. Patients with psoriasis were compared to controls regarding the prevalence of OSA in a case-control study. A logistic multivariate model was used to control for independent covariates. RESULTS: The study included 12,336 patients with psoriasis ≥21 years and 24,008 age- and sex-matched controls. The prevalence of OSA in patients with psoriasis was increased compared to the control group (2.7%, 1.5%, respectively, P < 0.001). Multivariate analysis adjusting for age, sex, ethnicity, body mass index, chronic obstructive pulmonary disease, hypothyroidism, hyperlipidemia, and peptic disease demonstrated a significant association between psoriasis and OSA (odds ratio = 1.27, 95% confidence interval 1.08-1.49, P < 0.001). CONCLUSION: We found an association between psoriasis and OSA among a large cohort of patients with psoriasis. Clinicians should take into account that patients with psoriasis may have undiagnosed OSA.
BACKGROUND:Psoriasis is a chronic inflammatory skin disorder that is associated with the metabolic syndrome and its components. An association between obstructive sleep apnea (OSA) and the metabolic syndrome was previously observed. OBJECTIVES: To investigate the association between psoriasis and OSA in a comprehensive community-based database. MATERIALS AND METHODS: The study was performed utilizing the medical database of Clalit Health Services. Patients with psoriasis were compared to controls regarding the prevalence of OSA in a case-control study. A logistic multivariate model was used to control for independent covariates. RESULTS: The study included 12,336 patients with psoriasis ≥21 years and 24,008 age- and sex-matched controls. The prevalence of OSA in patients with psoriasis was increased compared to the control group (2.7%, 1.5%, respectively, P < 0.001). Multivariate analysis adjusting for age, sex, ethnicity, body mass index, chronic obstructive pulmonary disease, hypothyroidism, hyperlipidemia, and peptic disease demonstrated a significant association between psoriasis and OSA (odds ratio = 1.27, 95% confidence interval 1.08-1.49, P < 0.001). CONCLUSION: We found an association between psoriasis and OSA among a large cohort of patients with psoriasis. Clinicians should take into account that patients with psoriasis may have undiagnosed OSA.
Authors: Qi Zheng; Xiao Ying Sun; Xiao Miao; Rong Xu; Tian Ma; Ya Nan Zhang; Hong Jin Li; Bin Li; Xin Li Journal: Medicine (Baltimore) Date: 2018-07 Impact factor: 1.889
Authors: Mary Patricia Smith; Karen Ly; Quinn Thibodeaux; Thulasi Weerasinghe; Kristen Beck; Lindsey Shankle; April W Armstrong; Marc Boas; Alisha Bridges; Frank Doris; Joel M Gelfand; Brian Lafoy; Ana-Maria Orbai; Junko Takeshita; Sarah Truman; Marilyn T Wan; Jashin J Wu; Michael P Siegel; Stacie J Bell; Tina Bhutani; Wilson Liao Journal: Dermatol Ther (Heidelb) Date: 2019-06-08