Jennifer J Carroll1, Renee Heffron, Nelly Mugo, Kenneth Ngure, Patrick Ndase, Stephen Asiimwe, Connie Celum, Jared M Baeten. 1. From the *Department of Epidemiology, †Department of Anthropology, ‡Department of Global Health, University of Washington, Seattle, WA; §Kenya Medical Research Institute; ‖Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya; ¶International Clinical Research Center, University of Washington, Seattle, WA; **Kabwohe Clinical Research Center, Kabwohe, Uganda; ††Department of Medicine, University of Washington, Seattle, WA.
Abstract
OBJECTIVES: Perceived risk of human immunodeficiency virus (HIV) infection is thought to drive low adherence in pre-exposure prophylaxis (PrEP) trials. We explored the level of perceived risk of incident HIV infection in the Partners PrEP Study, in which adherence was generally high. METHODS: A cross-sectional questionnaire assessed perceived risk of HIV at 12 months after enrollment. Logistic regression was used to analyze the relationship between perceived risk and other demographic and behavioral variables. RESULTS:Three thousand two hundred twenty-six couples from the Partners PrEP Study were included in this analysis. Only 15.4% of participants reported high or moderate perceived risk. Participants at high risk of acquiring HIV were slightly more likely to report high perceived risk (odds ratio, 1.60; 95% confidence interval, 1.30-1.95; P < 0.001); nevertheless, only 20% of participants with high-risk reported high perceived risk. CONCLUSIONS: Participants reported low perceived risk of HIV but were adherent to PrEP. Perceptions of risk are likely socially determined and more complex than Likert scale questionnaires capture.
RCT Entities:
OBJECTIVES: Perceived risk of human immunodeficiency virus (HIV) infection is thought to drive low adherence in pre-exposure prophylaxis (PrEP) trials. We explored the level of perceived risk of incident HIV infection in the Partners PrEP Study, in which adherence was generally high. METHODS: A cross-sectional questionnaire assessed perceived risk of HIV at 12 months after enrollment. Logistic regression was used to analyze the relationship between perceived risk and other demographic and behavioral variables. RESULTS: Three thousand two hundred twenty-six couples from the Partners PrEP Study were included in this analysis. Only 15.4% of participants reported high or moderate perceived risk. Participants at high risk of acquiring HIV were slightly more likely to report high perceived risk (odds ratio, 1.60; 95% confidence interval, 1.30-1.95; P < 0.001); nevertheless, only 20% of participants with high-risk reported high perceived risk. CONCLUSIONS:Participants reported low perceived risk of HIV but were adherent to PrEP. Perceptions of risk are likely socially determined and more complex than Likert scale questionnaires capture.
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