W Ma1,2, M Li3, F Gao4, X Zhang4, L Shi1, L Yu2, B Zhao4, W Chen5, G Wang6, X Wang7. 1. From the Department of Otolaryngology (W.M., L.S.). 2. the Second Hospital of Shandong University, The Central Hospital of Jinan City (W.M., L.Y.). 3. College of Electronics and Information Engineering (M.L.), Sichuan University, Chengdu, China. 4. Shandong Medical Imaging Research Institute (F.G., X.Z., B.Z., G.W.), Shandong University, Jinan, China. 5. Philips Healthcare (W.C.), Shanghai, China. 6. Shandong Medical Imaging Research Institute (F.G., X.Z., B.Z., G.W.), Shandong University, Jinan, China wgb7932596@hotmail.com. 7. the Department of Radiation Oncology (X.W.), University of Nebraska Medical Center, Omaha, Nebraska.
Abstract
BACKGROUND AND PURPOSE: Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data. MATERIALS AND METHODS: Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner. Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were obtained from the DTI data. Intergroup statistics were implemented on these measurements, which were transformed to Montreal Neurological Institute coordinates by using a nonrigid image registration method called large deformation diffeomorphic metric mapping. RESULTS: Increased axial diffusivity, radial diffusivity, and mean diffusivity and decreased fractional anisotropy were found near the right-side hearing-related areas in patients with presbycusis. Increased radial diffusivity and mean diffusivity were also found near a language-related area (Broca area) in patients with presbycusis. CONCLUSIONS: Our findings could be important for exploring reliable imaging evidence of presbycusis and could complement an ROI-based approach.
BACKGROUND AND PURPOSE: Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data. MATERIALS AND METHODS: Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner. Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were obtained from the DTI data. Intergroup statistics were implemented on these measurements, which were transformed to Montreal Neurological Institute coordinates by using a nonrigid image registration method called large deformation diffeomorphic metric mapping. RESULTS: Increased axial diffusivity, radial diffusivity, and mean diffusivity and decreased fractional anisotropy were found near the right-side hearing-related areas in patients with presbycusis. Increased radial diffusivity and mean diffusivity were also found near a language-related area (Broca area) in patients with presbycusis. CONCLUSIONS: Our findings could be important for exploring reliable imaging evidence of presbycusis and could complement an ROI-based approach.
Authors: Hangyi Jiang; Peter C M van Zijl; Jinsuh Kim; Godfrey D Pearlson; Susumu Mori Journal: Comput Methods Programs Biomed Date: 2006-01-18 Impact factor: 5.428
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