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Literature DB >> 27416800

Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.

Cara H Nelson¹, Chi-Chi Peng¹, Justin D Lutz¹, Catherine K Yeung¹, Alex Zelter², Nina Isoherranen¹.

Abstract

Cellular retinoic acid binding proteins (CRABPs) bind all-trans-retinoic acid (atRA) tightly. This study aimed to determine whether atRA is channeled directly to cytochrome P450 (CYP) CYP26B1 by CRABPs, and whether CRABPs interact directly with CYP26B1. atRA bound to CRABPs (holo-CRABP) was efficiently metabolized by CYP26B1. Isotope dilution experiments showed that delivery of atRA to CYP26B1 in solution was similar with or without CRABP. Holo-CRABPs had higher affinity for CYP26B1 than free atRA, but both apo-CRABPs inhibited the formation of 4-OH-RA by CYP26B1. Similar protein-protein interactions between soluble binding proteins and CYPs may be important for other lipophilic CYP substrates.

Entities: CellLine Chemical Disease Gene Species

Keywords: binding proteins; cytochrome P450; retinoic acid; substrate channeling

Mesh：

Substances：

Year: 2016 PMID： 27416800 PMCID： PMC4997814 DOI： 10.1002/1873-3468.12303

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

24 in total

1. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.

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Journal: Proc Natl Acad Sci U S A Date: 2000-06-06 Impact factor: 11.205

2. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.

Authors: Anuradha S Budhu; Noa Noy
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Review 4. Cytochrome P450s in the regulation of cellular retinoic acid metabolism.

Authors: A Catharine Ross; Reza Zolfaghari
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5. Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.

Authors: Justin D Lutz; Vaishali Dixit; Catherine K Yeung; Leslie J Dickmann; Alex Zelter; Jayne E Thatcher; Wendel L Nelson; Nina Isoherranen
Journal: Biochem Pharmacol Date: 2008-10-17 Impact factor: 5.858

6. Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes.

Authors: Jakob A Shimshoni; Arthur G Roberts; Michele Scian; Ariel R Topletz; Sean A Blankert; James R Halpert; Wendel L Nelson; Nina Isoherranen
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7. Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism.

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8. The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells.

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9. Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.

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Journal: Proc Natl Acad Sci U S A Date: 2008-10-06 Impact factor: 11.205

Review 10. Retinoic acid in the development, regeneration and maintenance of the nervous system.

Authors: Malcolm Maden
Journal: Nat Rev Neurosci Date: 2007-10 Impact factor: 34.870

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Review 4. Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases.

Authors: Joseph L Napoli
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5. The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance.

Authors: Guo Zhong; Cathryn Hogarth; Jessica M Snyder; Laura Palau; Traci Topping; Weize Huang; Lindsay C Czuba; Jeffrey LaFrance; Gabriel Ghiaur; Nina Isoherranen
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