Thorkild Ia Sørensen1, Teresa Adeltoft Ajslev2, Lars Ängquist2, Camilla Schmidt Morgen2, Ioana Gabriela Ciuchi2, George Davey Smith3. 1. Institute of Preventive Medicine, Frederiksberg and Bispebjerg University Hospital, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; and Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, Bristol University, Bristol, United Kingdom tsoe0005@regionh.dk. 2. Institute of Preventive Medicine, Frederiksberg and Bispebjerg University Hospital, Copenhagen, Denmark; 3. Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, Bristol University, Bristol, United Kingdom.
Abstract
BACKGROUND: Maternal prepregnancy adiposity may influence child adiposity beyond the transmitted genetic effects, which, if true, may accelerate the obesity epidemic, but the evidence for this mechanism is inconsistent. OBJECTIVE: The aim was to assess whether the associations of maternal body mass index (BMI) with child anthropometric measurements from birth through infancy and at 7 y of age exceed those of paternal associations. DESIGN: In the Danish National Birth Cohort, information on parental and child anthropometric measures is available for 30,655 trio families from maternal interviews during pregnancy and the postpartum period and from a 7-y follow-up. By using multiple linear and logistic regression models of child SD (z) scores of weight and BMI at birth, 5 mo, 12 mo, and 7 y of age, and of child overweight at age 7 y, we compared associations with maternal prepregnancy and postpartum BMI z scores and with paternal BMI z scores. RESULTS: When comparing maternal-child and paternal-child BMI z score associations, the strongest associations were observed with mothers' BMI at birth [maternal and paternal BMI z scores: 0.143 (95% CI: 0.130, 0.155) and 0.017 (95% CI: 0.005, 0.029), respectively] and throughout infancy, but the relative difference in the associations declined by child age [for BMI z score at child age 7 y per maternal and paternal BMI z scores: 0.208 (95% CI: 0.196, 0.220) and 0.154 (95% CI: 0.143, 0.166), respectively]. At 7 y of age, ORs of child overweight were 2.30 (95% CI: 1.99, 2.67) by maternal overweight and 1.96 (95% CI: 1.74, 2.21) by paternal overweight. There were no differences between the results based on maternal BMI before and after pregnancy or on child's weight adjusted for length or height. CONCLUSIONS: The associations of child weight and BMI with maternal BMI were stronger than with paternal BMI. The differences between the associations were strong at birth but declined with child aging.
BACKGROUND: Maternal prepregnancy adiposity may influence child adiposity beyond the transmitted genetic effects, which, if true, may accelerate the obesity epidemic, but the evidence for this mechanism is inconsistent. OBJECTIVE: The aim was to assess whether the associations of maternal body mass index (BMI) with child anthropometric measurements from birth through infancy and at 7 y of age exceed those of paternal associations. DESIGN: In the Danish National Birth Cohort, information on parental and child anthropometric measures is available for 30,655 trio families from maternal interviews during pregnancy and the postpartum period and from a 7-y follow-up. By using multiple linear and logistic regression models of child SD (z) scores of weight and BMI at birth, 5 mo, 12 mo, and 7 y of age, and of child overweight at age 7 y, we compared associations with maternal prepregnancy and postpartum BMI z scores and with paternal BMI z scores. RESULTS: When comparing maternal-child and paternal-child BMI z score associations, the strongest associations were observed with mothers' BMI at birth [maternal and paternal BMI z scores: 0.143 (95% CI: 0.130, 0.155) and 0.017 (95% CI: 0.005, 0.029), respectively] and throughout infancy, but the relative difference in the associations declined by child age [for BMI z score at child age 7 y per maternal and paternal BMI z scores: 0.208 (95% CI: 0.196, 0.220) and 0.154 (95% CI: 0.143, 0.166), respectively]. At 7 y of age, ORs of child overweight were 2.30 (95% CI: 1.99, 2.67) by maternal overweight and 1.96 (95% CI: 1.74, 2.21) by paternal overweight. There were no differences between the results based on maternal BMI before and after pregnancy or on child's weight adjusted for length or height. CONCLUSIONS: The associations of child weight and BMI with maternal BMI were stronger than with paternal BMI. The differences between the associations were strong at birth but declined with child aging.
Authors: S E Benjamin Neelon; C Schmidt Morgen; M Kamper-Jørgensen; E Oken; M W Gillman; J A Gallis; T I A Sørensen Journal: Pediatr Obes Date: 2017-03-15 Impact factor: 4.000
Authors: C S Morgen; L Ängquist; J L Baker; A M N Andersen; K F Michaelsen; T I A Sørensen Journal: Int J Obes (Lond) Date: 2017-09-08 Impact factor: 5.095
Authors: Nicole M Warrington; Robin N Beaumont; Momoko Horikoshi; Felix R Day; Øyvind Helgeland; Charles Laurin; Jonas Bacelis; Shouneng Peng; Ke Hao; Bjarke Feenstra; Andrew R Wood; Anubha Mahajan; Jessica Tyrrell; Neil R Robertson; N William Rayner; Zhen Qiao; Gunn-Helen Moen; Marc Vaudel; Carmen J Marsit; Jia Chen; Michael Nodzenski; Theresia M Schnurr; Mohammad H Zafarmand; Jonathan P Bradfield; Niels Grarup; Marjolein N Kooijman; Ruifang Li-Gao; Frank Geller; Tarunveer S Ahluwalia; Lavinia Paternoster; Rico Rueedi; Ville Huikari; Jouke-Jan Hottenga; Leo-Pekka Lyytikäinen; Alana Cavadino; Sarah Metrustry; Diana L Cousminer; Ying Wu; Elisabeth Thiering; Carol A Wang; Christian T Have; Natalia Vilor-Tejedor; Peter K Joshi; Jodie N Painter; Ioanna Ntalla; Ronny Myhre; Niina Pitkänen; Elisabeth M van Leeuwen; Raimo Joro; Vasiliki Lagou; Rebecca C Richmond; Ana Espinosa; Sheila J Barton; Hazel M Inskip; John W Holloway; Loreto Santa-Marina; Xavier Estivill; Wei Ang; Julie A Marsh; Christoph Reichetzeder; Letizia Marullo; Berthold Hocher; Kathryn L Lunetta; Joanne M Murabito; Caroline L Relton; Manolis Kogevinas; Leda Chatzi; Catherine Allard; Luigi Bouchard; Marie-France Hivert; Ge Zhang; Louis J Muglia; Jani Heikkinen; Camilla S Morgen; Antoine H C van Kampen; Barbera D C van Schaik; Frank D Mentch; Claudia Langenberg; Jian'an Luan; Robert A Scott; Jing Hua Zhao; Gibran Hemani; Susan M Ring; Amanda J Bennett; Kyle J Gaulton; Juan Fernandez-Tajes; Natalie R van Zuydam; Carolina Medina-Gomez; Hugoline G de Haan; Frits R Rosendaal; Zoltán Kutalik; Pedro Marques-Vidal; Shikta Das; Gonneke Willemsen; Hamdi Mbarek; Martina Müller-Nurasyid; Marie Standl; Emil V R Appel; Cilius E Fonvig; Caecilie Trier; Catharina E M van Beijsterveldt; Mario Murcia; Mariona Bustamante; Sílvia Bonas-Guarch; David M Hougaard; Josep M Mercader; Allan Linneberg; Katharina E Schraut; Penelope A Lind; Sarah E Medland; Beverley M Shields; Bridget A Knight; Jin-Fang Chai; Kalliope Panoutsopoulou; Meike Bartels; Friman Sánchez; Jakob Stokholm; David Torrents; Rebecca K Vinding; Sara M Willems; Mustafa Atalay; Bo L Chawes; Peter Kovacs; Inga Prokopenko; Marcus A Tuke; Hanieh Yaghootkar; Katherine S Ruth; Samuel E Jones; Po-Ru Loh; Anna Murray; Michael N Weedon; Anke Tönjes; Michael Stumvoll; Kim F Michaelsen; Aino-Maija Eloranta; Timo A Lakka; Cornelia M van Duijn; Wieland Kiess; Antje Körner; Harri Niinikoski; Katja Pahkala; Olli T Raitakari; Bo Jacobsson; Eleftheria Zeggini; George V Dedoussis; Yik-Ying Teo; Seang-Mei Saw; Grant W Montgomery; Harry Campbell; James F Wilson; Tanja G M Vrijkotte; Martine Vrijheid; Eco J C N de Geus; M Geoffrey Hayes; Haja N Kadarmideen; Jens-Christian Holm; Lawrence J Beilin; Craig E Pennell; Joachim Heinrich; Linda S Adair; Judith B Borja; Karen L Mohlke; Johan G Eriksson; Elisabeth E Widén; Andrew T Hattersley; Tim D Spector; Mika Kähönen; Jorma S Viikari; Terho Lehtimäki; Dorret I Boomsma; Sylvain Sebert; Peter Vollenweider; Thorkild I A Sørensen; Hans Bisgaard; Klaus Bønnelykke; Jeffrey C Murray; Mads Melbye; Ellen A Nohr; Dennis O Mook-Kanamori; Fernando Rivadeneira; Albert Hofman; Janine F Felix; Vincent W V Jaddoe; Torben Hansen; Charlotta Pisinger; Allan A Vaag; Oluf Pedersen; André G Uitterlinden; Marjo-Riitta Järvelin; Christine Power; Elina Hyppönen; Denise M Scholtens; William L Lowe; George Davey Smith; Nicholas J Timpson; Andrew P Morris; Nicholas J Wareham; Hakon Hakonarson; Struan F A Grant; Timothy M Frayling; Debbie A Lawlor; Pål R Njølstad; Stefan Johansson; Ken K Ong; Mark I McCarthy; John R B Perry; David M Evans; Rachel M Freathy Journal: Nat Genet Date: 2019-05-01 Impact factor: 38.330
Authors: Gemma C Sharp; Lucas A Salas; Claire Monnereau; Catherine Allard; Paul Yousefi; Todd M Everson; Jon Bohlin; Zongli Xu; Rae-Chi Huang; Sarah E Reese; Cheng-Jian Xu; Nour Baïz; Cathrine Hoyo; Golareh Agha; Ritu Roy; John W Holloway; Akram Ghantous; Simon K Merid; Kelly M Bakulski; Leanne K Küpers; Hongmei Zhang; Rebecca C Richmond; Christian M Page; Liesbeth Duijts; Rolv T Lie; Phillip E Melton; Judith M Vonk; Ellen A Nohr; ClarLynda Williams-DeVane; Karen Huen; Sheryl L Rifas-Shiman; Carlos Ruiz-Arenas; Semira Gonseth; Faisal I Rezwan; Zdenko Herceg; Sandra Ekström; Lisa Croen; Fahimeh Falahi; Patrice Perron; Margaret R Karagas; Bilal M Quraishi; Matthew Suderman; Maria C Magnus; Vincent W V Jaddoe; Jack A Taylor; Denise Anderson; Shanshan Zhao; Henriette A Smit; Michele J Josey; Asa Bradman; Andrea A Baccarelli; Mariona Bustamante; Siri E Håberg; Göran Pershagen; Irva Hertz-Picciotto; Craig Newschaffer; Eva Corpeleijn; Luigi Bouchard; Debbie A Lawlor; Rachel L Maguire; Lisa F Barcellos; George Davey Smith; Brenda Eskenazi; Wilfried Karmaus; Carmen J Marsit; Marie-France Hivert; Harold Snieder; M Daniele Fallin; Erik Melén; Monica C Munthe-Kaas; Hasan Arshad; Joseph L Wiemels; Isabella Annesi-Maesano; Martine Vrijheid; Emily Oken; Nina Holland; Susan K Murphy; Thorkild I A Sørensen; Gerard H Koppelman; John P Newnham; Allen J Wilcox; Wenche Nystad; Stephanie J London; Janine F Felix; Caroline L Relton Journal: Hum Mol Genet Date: 2017-10-15 Impact factor: 6.150