| Literature DB >> 31043758 |
Nicole M Warrington1, Robin N Beaumont2, Momoko Horikoshi3,4,5, Felix R Day6, Øyvind Helgeland7,8,9, Charles Laurin10,11, Jonas Bacelis12, Shouneng Peng13,14, Ke Hao13,14, Bjarke Feenstra15, Andrew R Wood2, Anubha Mahajan4,5, Jessica Tyrrell2,16, Neil R Robertson4,5, N William Rayner4,5,17, Zhen Qiao1, Gunn-Helen Moen18,19, Marc Vaudel7, Carmen J Marsit20, Jia Chen21, Michael Nodzenski22, Theresia M Schnurr23, Mohammad H Zafarmand24,25, Jonathan P Bradfield26,27, Niels Grarup23, Marjolein N Kooijman28,29,30, Ruifang Li-Gao31, Frank Geller15, Tarunveer S Ahluwalia23,32,33, Lavinia Paternoster10, Rico Rueedi34,35, Ville Huikari36, Jouke-Jan Hottenga37,38,39, Leo-Pekka Lyytikäinen40,41, Alana Cavadino42,43, Sarah Metrustry44, Diana L Cousminer45,46, Ying Wu47, Elisabeth Thiering48,49, Carol A Wang50, Christian T Have23, Natalia Vilor-Tejedor51,52, Peter K Joshi53, Jodie N Painter54, Ioanna Ntalla55, Ronny Myhre56, Niina Pitkänen57, Elisabeth M van Leeuwen29, Raimo Joro58, Vasiliki Lagou4,59,60, Rebecca C Richmond10,11, Ana Espinosa61,62,63,64, Sheila J Barton65, Hazel M Inskip65,66, John W Holloway67, Loreto Santa-Marina63,68,69, Xavier Estivill70,71, Wei Ang72, Julie A Marsh72, Christoph Reichetzeder73, Letizia Marullo74, Berthold Hocher75,76, Kathryn L Lunetta77,78, Joanne M Murabito78,79, Caroline L Relton10,11, Manolis Kogevinas61,62,63,64, Leda Chatzi80, Catherine Allard81, Luigi Bouchard81,82,83, Marie-France Hivert84,85,86, Ge Zhang87,88,89, Louis J Muglia87,88,89, Jani Heikkinen90, Camilla S Morgen91, Antoine H C van Kampen92,93, Barbera D C van Schaik92, Frank D Mentch26, Claudia Langenberg6, Jian'an Luan6, Robert A Scott6, Jing Hua Zhao6, Gibran Hemani10,11, Susan M Ring10,11, Amanda J Bennett5, Kyle J Gaulton4,94, Juan Fernandez-Tajes4, Natalie R van Zuydam4,5, Carolina Medina-Gomez28,29,95, Hugoline G de Haan31, Frits R Rosendaal31, Zoltán Kutalik35,96, Pedro Marques-Vidal97, Shikta Das98, Gonneke Willemsen37,38,39, Hamdi Mbarek37,38,39,99, Martina Müller-Nurasyid100,101,102, Marie Standl48, Emil V R Appel23, Cilius E Fonvig23,103,104, Caecilie Trier23,103, Catharina E M van Beijsterveldt38, Mario Murcia63,105, Mariona Bustamante61,62,63, Sílvia Bonas-Guarch106, David M Hougaard107, Josep M Mercader106,108,109, Allan Linneberg110,111, Katharina E Schraut53, Penelope A Lind54, Sarah E Medland54, Beverley M Shields112, Bridget A Knight112, Jin-Fang Chai113, Kalliope Panoutsopoulou17, Meike Bartels37,38,39, Friman Sánchez106,114, Jakob Stokholm32, David Torrents106,115, Rebecca K Vinding32, Sara M Willems29, Mustafa Atalay58, Bo L Chawes32, Peter Kovacs116, Inga Prokopenko4,117, Marcus A Tuke2, Hanieh Yaghootkar2, Katherine S Ruth2, Samuel E Jones2, Po-Ru Loh118,119, Anna Murray2, Michael N Weedon2, Anke Tönjes120, Michael Stumvoll116,120, Kim F Michaelsen121, Aino-Maija Eloranta58, Timo A Lakka58,122,123, Cornelia M van Duijn29, Wieland Kiess124, Antje Körner116,124, Harri Niinikoski125,126, Katja Pahkala57,127, Olli T Raitakari57,128, Bo Jacobsson9,12, Eleftheria Zeggini17,129, George V Dedoussis130, Yik-Ying Teo113,131,132, Seang-Mei Saw113,133, Grant W Montgomery54, Harry Campbell53, James F Wilson53,134, Tanja G M Vrijkotte24, Martine Vrijheid61,62,63, Eco J C N de Geus37,38,39, M Geoffrey Hayes135, Haja N Kadarmideen136, Jens-Christian Holm23,103, Lawrence J Beilin137, Craig E Pennell50, Joachim Heinrich48,138, Linda S Adair139, Judith B Borja140,141, Karen L Mohlke47, Johan G Eriksson142,143,144, Elisabeth E Widén90, Andrew T Hattersley2,112, Tim D Spector44, Mika Kähönen145,146, Jorma S Viikari147,148, Terho Lehtimäki40,41, Dorret I Boomsma37,38,39,99, Sylvain Sebert36,149,150,151, Peter Vollenweider97, Thorkild I A Sørensen10,23,91, Hans Bisgaard32, Klaus Bønnelykke32, Jeffrey C Murray152, Mads Melbye15,153, Ellen A Nohr154, Dennis O Mook-Kanamori31,155, Fernando Rivadeneira28,29,95, Albert Hofman29, Janine F Felix28,29,30, Vincent W V Jaddoe28,29,30, Torben Hansen23, Charlotta Pisinger156, Allan A Vaag110,157, Oluf Pedersen23, André G Uitterlinden28,29,95, Marjo-Riitta Järvelin36,149,150,158,159, Christine Power43, Elina Hyppönen43,160,161, Denise M Scholtens22, William L Lowe135, George Davey Smith10,11,162, Nicholas J Timpson10,11, Andrew P Morris4,163,164, Nicholas J Wareham6, Hakon Hakonarson26,45,165, Struan F A Grant26,45,46,165, Timothy M Frayling2, Debbie A Lawlor10,11,162, Pål R Njølstad7,8, Stefan Johansson7,166, Ken K Ong6,167, Mark I McCarthy4,5,168, John R B Perry6, David M Evans169,170,171, Rachel M Freathy172,173.
Abstract
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.Entities:
Mesh：
Year: 2019 PMID： 31043758 PMCID： PMC6522365 DOI： 10.1038/s41588-019-0403-1
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330