Yan Zheng1, Yanping Li1, Qibin Qi2, Adela Hruby1, JoAnn E Manson3,4,5, Walter C Willett1,3,4, Brian M Wolpin6, Frank B Hu1,3,4, Lu Qi7,8. 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 2. Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. 3. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 4. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. 6. Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. 7. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA lqi1@tulane.edu. 8. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Abstract
BACKGROUND: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. METHODS: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). RESULTS: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01). CONCLUSIONS: Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.
BACKGROUND: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. METHODS: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). RESULTS: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01). CONCLUSIONS: Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.
Authors: J E Manson; G A Colditz; M J Stampfer; W C Willett; A S Krolewski; B Rosner; R A Arky; F E Speizer; C H Hennekens Journal: Arch Intern Med Date: 1991-06
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: Christopher B Newgard; Jie An; James R Bain; Michael J Muehlbauer; Robert D Stevens; Lillian F Lien; Andrea M Haqq; Svati H Shah; Michelle Arlotto; Cris A Slentz; James Rochon; Dianne Gallup; Olga Ilkayeva; Brett R Wenner; William S Yancy; Howard Eisenson; Gerald Musante; Richard S Surwit; David S Millington; Mark D Butler; Laura P Svetkey Journal: Cell Metab Date: 2009-04 Impact factor: 27.287
Authors: David J A Jenkins; Cyril W C Kendall; Livia S A Augustin; Silvia Franceschi; Maryam Hamidi; Augustine Marchie; Alexandra L Jenkins; Mette Axelsen Journal: Am J Clin Nutr Date: 2002-07 Impact factor: 7.045
Authors: Denise M Scholtens; Michael J Muehlbauer; Natalie R Daya; Robert D Stevens; Alan R Dyer; Lynn P Lowe; Boyd E Metzger; Christopher B Newgard; James R Bain; William L Lowe Journal: Diabetes Care Date: 2013-08-29 Impact factor: 19.112
Authors: Ryoko Katagiri; Mingyang Song; Xuehong Zhang; Dong Hoon Lee; Fred K Tabung; Charles S Fuchs; Jeffrey A Meyerhardt; Reiko Nishihara; Andrew T Chan; Amit D Joshi; Motoki Iwasaki; Shuji Ogino; Walter C Willett; Edward Giovannucci; Kana Wu Journal: Cancer Prev Res (Phila) Date: 2019-11-07
Authors: Miguel Ruiz-Canela; Marta Guasch-Ferré; Estefanía Toledo; Clary B Clish; Cristina Razquin; Liming Liang; Dong D Wang; Dolores Corella; Ramón Estruch; Álvaro Hernáez; Edward Yu; Enrique Gómez-Gracia; Yan Zheng; Fernando Arós; Dora Romaguera; Courtney Dennis; Emilio Ros; José Lapetra; Lluis Serra-Majem; Christopher Papandreou; Olga Portoles; Montserrat Fitó; Jordi Salas-Salvadó; Frank B Hu; Miguel A Martínez-González Journal: Diabetologia Date: 2018-04-16 Impact factor: 10.122
Authors: George A Bray; Leanne M Redman; Lilian de Jonge; Jennifer Rood; Elizabeth F Sutton; Steven R Smith Journal: Obesity (Silver Spring) Date: 2017-12-27 Impact factor: 5.002
Authors: Samantha M Solon-Biet; Victoria C Cogger; Tamara Pulpitel; Devin Wahl; Ximonie Clark; Elena Bagley; Gabrielle C Gregoriou; Alistair M Senior; Qiao-Ping Wang; Amanda E Brandon; Ruth Perks; John O'Sullivan; Yen Chin Koay; Kim Bell-Anderson; Melkam Kebede; Belinda Yau; Clare Atkinson; Gunbjorg Svineng; Timothy Dodgson; Jibran A Wali; Matthew D W Piper; Paula Juricic; Linda Partridge; Adam J Rose; David Raubenheimer; Gregory J Cooney; David G Le Couteur; Stephen J Simpson Journal: Nat Metab Date: 2019-04-29