| Literature DB >> 27412492 |
Tara Shabab1, Ramin Khanabdali2,3, Soheil Zorofchian Moghadamtousi1, Habsah Abdul Kadir1, Gokula Mohan1.
Abstract
Activated microglial cells play an important role in immune and inflammatory responses in central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are mediated by signaling molecules that are produced during neuroinflammation. In glial cells, NF-κB, a transcription factor, initiates and regulates the expression of several inflammatory processes during inflammation which are attributed to the pathology of the several neurodegenerative diseases. In this review, we discuss the most important neuroinflammatory mediators with their pathways. Attenuating cytokines production and controlling microglial inflammatory response, which are the result of understanding neuroinflammation pathways, are considered therapeutic strategies for treating neurodegenerative diseases with an inflammatory component.Entities:
Keywords: NF-κB pathway; microglia; neuroinflammation; neuroinflammatory diseases
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Year: 2016 PMID： 27412492 DOI： 10.1080/00207454.2016.1212854
Source DB: PubMed Journal: Int J Neurosci ISSN： 0020-7454 Impact factor: 2.292