Literature DB >> 27408358

Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases.

M Bchir1, W Ayed2, H Ben Neji1, O Kilani2, S Kefi1, M Zarrouk1, H Guermani2, S Hentati2, A Amouri2, B Meddeb1.   

Abstract

Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.

Entities:  

Keywords:  Acute promyelocytic leukemia; Chronic myelogenous leukemia; Karyotype; Klinefelter syndrome

Year:  2015        PMID： 27408358      PMCID： PMC4925523          DOI： 10.1007/s12288-015-0590-6

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN： 0971-4502            Impact factor:   0.900


  9 in total

1.  Unsuspected Klinefelter syndrome diagnosed during oncologic evaluation: a case series.

Authors:  Margaret M Eberl; Maria R Baer; Martin C Mahoney; Sheila N J Sait; Annemarie W Block; Carolyn D Farrell
Journal:  J Am Board Fam Pract       Date:  2005 Mar-Apr

2.  Klinefelter's syndrome and acute leukemia.

Authors:  D E Horsman; J T Pantzar; F J Dill; D K Kalousek
Journal:  Cancer Genet Cytogenet       Date:  1987-06

3.  Translocation (15;17)(q22;q21) in a patient with Klinefelter syndrome.

Authors:  J L García; J M Hernández; M González; J F San Miguel; P Dal Cin; H Van Den Berghe
Journal:  Cancer Genet Cytogenet       Date:  1996-01

4.  Persistent suboptimal molecular response in a patient with chronic myelogenous leukemia and Klinefelter syndrome.

Authors:  Rajshekhar Chakraborty; Shiva Kumar Reddy Mukkamalla; Kranthi Singam; Natalia Calderon
Journal:  Korean J Intern Med       Date:  2014-10-31       Impact factor: 2.884

5.  Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study.

Authors:  Anthony J Swerdlow; Minouk J Schoemaker; Craig D Higgins; Alan F Wright; Patricia A Jacobs
Journal:  J Natl Cancer Inst       Date:  2005-08-17       Impact factor: 13.506

6.  Allogeneic bone marrow transplantation from an unrelated donor for the treatment of chronic myelogenous leukemia in blast crisis in a patient with Kleinfelter's syndrome.

Authors:  Tomomi Toubai; Junji Tanaka; Shuichi Ota; Yoko Miura; Nobuyasu Toyoshima; Masahiro Asaka; Masahiro Imamura
Journal:  Leuk Lymphoma       Date:  2004-04

7.  Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome.

Authors:  Vanya Slavcheva; Tzvetan Lukanov; Gueorgui Balatsenko; Svetlana Angelova; Antonio Antonov; Lachezar Bogdanov; Nikolay Tsvetkov
Journal:  Hematol Rep       Date:  2010-12-22

8.  Chronic myeloid leukemia in case of Klinefelter syndrome.

Authors:  Vasundhara Chennuri; Rajesh Kashyap; Parag Tamhankar; Subha Phadke
Journal:  Indian J Hum Genet       Date:  2014-01

9.  Cancer incidence in men with Klinefelter syndrome.

Authors:  H Hasle; A Mellemgaard; J Nielsen; J Hansen
Journal:  Br J Cancer       Date:  1995-02       Impact factor: 7.640
  9 in total

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