Literature DB >> 27408292

Bioshock: Biotechnology and Bioterrorism.

N Moorchung1, A K Sharma2, S R Mehta3.   

Abstract

In the recent past, the threat of a global bioterrorist attack has increased dramatically. In addition to the already existing microorganisms and techniques, the recent explosion in biotechnology has considerably added to the arsenal of the bioterrorist. Molecular technologies are now available which can be used by committed bioterrorist groups to manipulate and modify microorganisms so as to make them increasingly infectious, virulent or treatment resistant for causing maximum casualties. Infectious diseases which are likely to be used as bioweapons are Anthrax, Botulism, Plague, Smallpox and Brucella. Molecular techniques like immunoassays and nucleic acid amplification are now available to detect bioattacks. This article discusses the threat of bioterrorism. It also evaluates the molecular diagnostic methods and the future of early containment of a bioterrorist attack using molecular techniques.

Entities:  

Keywords:  Bioterrorism; Molecular techniques

Year:  2011        PMID: 27408292      PMCID: PMC4921357          DOI: 10.1016/S0377-1237(09)80100-7

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN: 0377-1237


  27 in total

1.  Recombinant antibodies: a new reagent for biological agent detection.

Authors:  P A Emanuel; J Dang; J S Gebhardt; J Aldrich; E A Garber; H Kulaga; P Stopa; J J Valdes; A Dion-Schultz
Journal:  Biosens Bioelectron       Date:  2000-01       Impact factor: 10.618

2.  Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.

Authors:  J D WATSON; F H CRICK
Journal:  Nature       Date:  1953-04-25       Impact factor: 49.962

3.  Real time quantitative PCR.

Authors:  C A Heid; J Stevens; K J Livak; P M Williams
Journal:  Genome Res       Date:  1996-10       Impact factor: 9.043

4.  Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

Authors:  R J Jackson; A J Ramsay; C D Christensen; S Beaton; D F Hall; I A Ramshaw
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

5.  Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin.

Authors:  M L Cunningham; R G Titus; S J Turco; S M Beverley
Journal:  Science       Date:  2001-04-13       Impact factor: 47.728

6.  A MEMS based amperometric detector for E. coli bacteria using self-assembled monolayers.

Authors:  J J Gau; E H Lan; B Dunn; C M Ho; J C Woo
Journal:  Biosens Bioelectron       Date:  2001-12       Impact factor: 10.618

7.  RNA biosensor for the rapid detection of viable Escherichia coli in drinking water.

Authors:  Antje J Baeumner; Richard N Cohen; Vonya Miksic; Junhong Min
Journal:  Biosens Bioelectron       Date:  2003-04       Impact factor: 10.618

8.  Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon.

Authors:  Nobuyuki Shimono; Lisa Morici; Nicola Casali; Sally Cantrell; Ben Sidders; Sabine Ehrt; Lee W Riley
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-08       Impact factor: 11.205

9.  Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.

Authors:  K J Livak; S J Flood; J Marmaro; W Giusti; K Deetz
Journal:  PCR Methods Appl       Date:  1995-06

10.  Direct PCR detection of Escherichia coli O157:H7.

Authors:  K A Fode-Vaughan; J S Maki; J A Benson; M L P Collins
Journal:  Lett Appl Microbiol       Date:  2003       Impact factor: 2.858

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