Borwin Bandelow1, David Baldwin2, Marianna Abelli3, Carlo Altamura4, Bernardo Dell'Osso4, Katharina Domschke5, Naomi A Fineberg6, Edna Grünblatt5,7,8,9, Marek Jarema10, Eduard Maron11,12,13, David Nutt13, Stefano Pini3, Matilde M Vaghi14, Adam Wichniak10, Gwyneth Zai14,15,16,17, Peter Riederer5,7,8. 1. a Department of Psychiatry and Psychotherapy , University of Göttingen , Germany ; 2. b Faculty of Medicine , University of Southampton , Southampton , UK ; 3. c Department of Clinical and Experimental Medicine , Section of Psychiatry, University of Pisa , Italy ; 4. d Department of Psychiatry , University of Milan; Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico , Milan , Italy ; 5. e Department of Psychiatry, Psychosomatics and Psychotherapy , University of Wuerzburg , Germany ; 6. f Hertfordshire Partnership University NHS Foundation Trust and University of Hertfordshire , Rosanne House, Parkway , Welwyn Garden City , UK ; 7. g Neuroscience Center Zurich , University of Zurich and the ETH Zurich , Zürich , Switzerland ; 8. h Department of Child and Adolescent Psychiatry and Psychotherapy , Psychiatric Hospital, University of Zurich , Zürich , Switzerland ; 9. i Zurich Center for Integrative Human Physiology , University of Zurich , Switzerland ; 10. j Third Department of Psychiatry , Institute of Psychiatry and Neurology , Warszawa , Poland ; 11. k North Estonia Medical Centre, Department of Psychiatry , Tallinn , Estonia ; 12. l Department of Psychiatry , University of Tartu , Estonia ; 13. m Faculty of Medicine, Department of Medicine, Centre for Neuropsychopharmacology, Division of Brain Sciences , Imperial College London , UK ; 14. n Department of Psychology and Behavioural and Clinical Neuroscience Institute , University of Cambridge , UK ; 15. o Neurogenetics Section, Centre for Addiction & Mental Health , Toronto , Canada ; 16. p Frederick W. Thompson Anxiety Disorders Centre, Department of Psychiatry, Sunnybrook Health Sciences Centre , Toronto , Canada ; 17. q Institute of Medical Science and Department of Psychiatry, University of Toronto , Toronto , Canada.
Abstract
OBJECTIVES: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network. RESULTS: The present article (Part I) summarises findings on potential biomarkers in neuroimaging studies, including structural brain morphology, functional magnetic resonance imaging and techniques for measuring metabolic changes, including positron emission tomography and others. Furthermore, this review reports on the clinical and molecular genetic findings of family, twin, linkage, association and genome-wide association studies. Part II of the review focuses on neurochemistry, neurophysiology and neurocognition. CONCLUSIONS: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high-quality research has accumulated that will improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
OBJECTIVES: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network. RESULTS: The present article (Part I) summarises findings on potential biomarkers in neuroimaging studies, including structural brain morphology, functional magnetic resonance imaging and techniques for measuring metabolic changes, including positron emission tomography and others. Furthermore, this review reports on the clinical and molecular genetic findings of family, twin, linkage, association and genome-wide association studies. Part II of the review focuses on neurochemistry, neurophysiology and neurocognition. CONCLUSIONS: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high-quality research has accumulated that will improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
Authors: Borwin Bandelow; David Baldwin; Marianna Abelli; Blanca Bolea-Alamanac; Michel Bourin; Samuel R Chamberlain; Eduardo Cinosi; Simon Davies; Katharina Domschke; Naomi Fineberg; Edna Grünblatt; Marek Jarema; Yong-Ku Kim; Eduard Maron; Vasileios Masdrakis; Olya Mikova; David Nutt; Stefano Pallanti; Stefano Pini; Andreas Ströhle; Florence Thibaut; Matilde M Vaghi; Eunsoo Won; Dirk Wedekind; Adam Wichniak; Jade Woolley; Peter Zwanzger; Peter Riederer Journal: World J Biol Psychiatry Date: 2016-07-15 Impact factor: 4.132
Authors: Benjamin Suarez-Jimenez; Xi Zhu; Amit Lazarov; J John Mann; Franklin Schneier; Andrew Gerber; Jacques P Barber; Dianne L Chambless; Yuval Neria; Barbara Milrod; John C Markowitz Journal: Psychol Med Date: 2019-02-18 Impact factor: 10.592
Authors: Nicole C R McLaughlin; Darin D Dougherty; Emad Eskandar; Herbert Ward; Kelly D Foote; Donald A Malone; Andre Machado; William Wong; Mark Sedrak; Wayne Goodman; Brian H Kopell; Fuad Issa; Donald C Shields; Osama A Abulseoud; Kendall Lee; Mark A Frye; Alik S Widge; Thilo Deckersbach; Michael S Okun; Dawn Bowers; Russell M Bauer; Dana Mason; Cynthia S Kubu; Ivan Bernstein; Kyle Lapidus; David L Rosenthal; Robert L Jenkins; Cynthia Read; Paul F Malloy; Stephen Salloway; David R Strong; Richard N Jones; Steven A Rasmussen; Benjamin D Greenberg Journal: Contemp Clin Trials Commun Date: 2021-06-05