| Literature DB >> 27399969 |
Li Yu1, Guo-Dong Wang2, Jue Ruan3,4, Yong-Bin Chen5, Cui-Ping Yang5, Xue Cao2,6, Hong Wu1,2,7,8, Yan-Hu Liu1,7, Zheng-Lin Du3, Xiao-Ping Wang1, Jing Yang1, Shao-Chen Cheng1,7, Li Zhong1, Lu Wang1, Xuan Wang2, Jing-Yang Hu1,2,7,8, Lu Fang3, Bing Bai1, Kai-Le Wang3, Na Yuan3, Shi-Fang Wu2, Bao-Guo Li9,10, Jin-Guo Zhang11, Ye-Qin Yang12, Cheng-Lin Zhang11, Yong-Cheng Long13, Hai-Shu Li14, Jing-Yuan Yang15, David M Irwin16, Oliver A Ryder17, Ying Li18, Chung-I Wu3,19, Ya-Ping Zhang2.
Abstract
The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti, Rhinopithecus roxellana, and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus avunculus inhabit lowland regions. We report the de novo whole-genome sequence of R. bieti and genomic sequences for the four other species. Eight shared substitutions were found in six genes related to lung function, DNA repair, and angiogenesis in the high-altitude snub-nosed monkeys. Functional assays showed that the high-altitude variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro. Genomic scans in the R. bieti and R. roxellana populations identified signatures of selection between and within populations at genes involved in functions relevant to high-altitude adaptation. These results provide valuable insights into the adaptation to high altitude in the snub-nosed monkeys.Entities:
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Year: 2016 PMID： 27399969 DOI： 10.1038/ng.3615
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330