| Literature DB >> 27399938 |
Hongbing Liu1, Katheryn Lohith1, Margaret Rosario1, Thomas H Pulliam1, Robert D O'Connor1, Lori J Bell2, Carole A Bewley1.
Abstract
Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL(-1) minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.Entities:
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Year: 2016 PMID: 27399938 PMCID: PMC6201272 DOI: 10.1021/acs.jnatprod.6b00229
Source DB: PubMed Journal: J Nat Prod ISSN: 0163-3864 Impact factor: 4.050