Literature DB >> 17378608

Eurysterols A and B, cytotoxic and antifungal steroidal sulfates from a marine sponge of the genus Euryspongia.

Chollaratt Boonlarppradab1, D John Faulkner.   

Abstract

Two new steroidal sulfates, eurysterols A (1) and B (2), were isolated from an undescribed marine sponge of the genus Euryspongia collected in Palau. The structures of the new compounds were assigned by NMR spectroscopic data interpretation. Compounds 1 and 2 showed cytotoxicity against human colon carcinoma (HCT-116) cells with IC50 values of 2.9 and 14.3 microg/mL, respectively, and exhibited antifungal activity against amphotericin B-resistant and wild-type strains of Candida albicans with MIC values, in turn, of 15.6 and 62.5 microg/mL.

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Year:  2007        PMID： 17378608     DOI： 10.1021/np060472c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

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Review 2.  Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.

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Review 3.  Antifungal and antiviral products of marine organisms.

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Journal:  Appl Microbiol Biotechnol       Date:  2014-02-23       Impact factor: 4.813

4.  Comparative study of chromatographic medium-associated mass and potential antitumor activity loss with bioactive extracts.

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Journal:  J Nat Prod       Date:  2013-02-26       Impact factor: 4.050

5.  Two new cytotoxic candidaspongiolides from an indonesian sponge.

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Journal:  ISRN Pharm       Date:  2011-07-18

6.  Marine Sponge Endosymbionts: Structural and Functional Specificity of the Microbiome within Euryspongia arenaria Cells.

Authors:  Qi Yang; Jackson K B Cahn; Jörn Piel; Yue-Fan Song; Wei Zhang; Hou-Wen Lin
Journal:  Microbiol Spectr       Date:  2022-05-02

Review 7.  Marine Sponges as a Drug Treasure.

Authors:  Komal Anjum; Syed Qamar Abbas; Sayed Asmat Ali Shah; Najeeb Akhter; Sundas Batool; Syed Shams Ul Hassan
Journal:  Biomol Ther (Seoul)       Date:  2016-07-01       Impact factor: 4.634

Review 8.  Secondary Metabolites from the Marine Sponge Genus Phyllospongia.

Authors:  Huawei Zhang; Menglian Dong; Hong Wang; Phillip Crews
Journal:  Mar Drugs       Date:  2017-01-06       Impact factor: 5.118

Review 9.  Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Nobuhiro Fusetani
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2010-09-15       Impact factor: 3.228

10.  Synthesis of the 8,19-Epoxysteroid Eurysterol A.

Authors:  Ömer Taspinar; Tobias Wilczek; Julian Erver; Martin Breugst; Jörg-Martin Neudörfl; Hans-Günther Schmalz
Journal:  Chemistry       Date:  2020-03-09       Impact factor: 5.236
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