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Literature DB >> 27394966

Mitochondrial UPR: A Double-Edged Sword.

Ye Tian¹, Carsten Merkwirth¹, Andrew Dillin².

Abstract

The mitochondrial unfolded protein response (UPR(mt)) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR(mt) activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPR(mt) and provides a possible therapeutic target for diseases associated with mtDNA mutations.

Entities: Disease Species

Keywords: ATFS-1; OXPHOS; UPR(mt); mitochondrial disease; mitochondrial heteroplasmy; mtDNA deletion

Mesh：

Substances：
DNA, Mitochondrial

Year: 2016 PMID： 27394966 DOI： 10.1016/j.tcb.2016.06.006

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

Keyword Cloud
Cited

16 in total

1. Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect.

Authors: Li Li; Chang-Sheng Wu; Guan-Mei Hou; Ming-Zhe Dong; Zhen-Bo Wang; Yi Hou; Heide Schatten; Gui-Rong Zhang; Qing-Yuan Sun
Journal: Reprod Biol Endocrinol Date: 2018-11-03 Impact factor: 5.211

Review 2. Cellular Metabolism and Aging.

Authors: Andre Catic
Journal: Prog Mol Biol Transl Sci Date: 2018-02-01 Impact factor: 3.622

3. High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice.

Authors: André Victor Cordeiro; Guilherme Francisco Peruca; Renata Rosseto Braga; Rafael Santos Brícola; Luciene Lenhare; Vagner Ramon Rodrigues Silva; Chadi Pellegrini Anaruma; Carlos Kiyoshi Katashima; Barbara Moreira Crisol; Lucas Torres Barbosa; Fernando Moreira Simabuco; Adelino Sanchez Ramos da Silva; Dennys Esper Cintra; Leandro Pereira de Moura; José Rodrigo Pauli; Eduardo Rochete Ropelle
Journal: Geroscience Date: 2020-07-31 Impact factor: 7.713

Review 4. Decoding the rosetta stone of mitonuclear communication.

Authors: Justin English; Jyung Mean Son; Maria Dafne Cardamone; Changhan Lee; Valentina Perissi
Journal: Pharmacol Res Date: 2020-08-23 Impact factor: 7.658

5. Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR^mt to promote metastasis.

Authors: T C Kenny; P Hart; M Ragazzi; M Sersinghe; J Chipuk; M A K Sagar; K W Eliceiri; T LaFramboise; S Grandhi; J Santos; A K Riar; L Papa; M D'Aurello; G Manfredi; M G Bonini; D Germain
Journal: Oncogene Date: 2017-04-03 Impact factor: 9.867

6. Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS.

Authors: Amanjot K Riar; Suzanne R Burstein; Gloria M Palomo; Andrea Arreguin; Giovanni Manfredi; Doris Germain
Journal: Hum Mol Genet Date: 2017-04-01 Impact factor: 5.121

Mitochondrial UPR: A Double-Edged Sword.

1. Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect.

Review 2. Cellular Metabolism and Aging.

3. High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice.

Review 4. Decoding the rosetta stone of mitonuclear communication.

5. Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR^mt to promote metastasis.

6. Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS.

Review 7. Sensing the Stress: A Role for the UPR^mt and UPR^am in the Quality Control of Mitochondria.

Review 8. Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction.

Review 9. Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise.

10. Role of Signaling Molecules in Mitochondrial Stress Response.

Mitochondrial UPR: A Double-Edged Sword.

1. Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect.

Review 2. Cellular Metabolism and Aging.

3. High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice.

Review 4. Decoding the rosetta stone of mitonuclear communication.

5. Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis.

6. Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS.

Review 7. Sensing the Stress: A Role for the UPRmt and UPRam in the Quality Control of Mitochondria.

Review 8. Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction.

Review 9. Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise.

10. Role of Signaling Molecules in Mitochondrial Stress Response.

5. Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR^mt to promote metastasis.

Review 7. Sensing the Stress: A Role for the UPR^mt and UPR^am in the Quality Control of Mitochondria.