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Literature DB >> 29653684

Cellular Metabolism and Aging.

Abstract

Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of relevant pathways can extend life span. In this review, we will outline how cellular biochemistry and energy homeostasis change during aging. We will highlight protein quality control, mitochondria, epigenetics, nutrient-sensing pathways, as well as the interplay between these systems with respect to their impact on cellular health.

Entities: Chemical Disease Gene Species

Keywords: epigenetics; mitochondria; nutrient-sensing pathways; proteostasis

Mesh：

Year: 2018 PMID： 29653684 PMCID： PMC5967871 DOI： 10.1016/bs.pmbts.2017.12.003

Source DB: PubMed Journal: Prog Mol Biol Transl Sci ISSN： 1877-1173 Impact factor: 3.622

132 in total

1. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors: Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

Review 2. Proteostasis and aging of stem cells.

Authors: David Vilchez; Milos S Simic; Andrew Dillin
Journal: Trends Cell Biol Date: 2013-10-03 Impact factor: 20.808

Review 3. Essential role for autophagy in life span extension.

Authors: Frank Madeo; Andreas Zimmermann; Maria Chiara Maiuri; Guido Kroemer
Journal: J Clin Invest Date: 2015-01-02 Impact factor: 14.808

Review 4. Autophagy at the crossroads of catabolism and anabolism.

Authors: Jasvinder Kaur; Jayanta Debnath
Journal: Nat Rev Mol Cell Biol Date: 2015-07-15 Impact factor: 94.444

5. Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Authors: Weijing Cai; Jaime Uribarri; Li Zhu; Xue Chen; Shobha Swamy; Zhengshan Zhao; Fabrizio Grosjean; Calogera Simonaro; George A Kuchel; Michal Schnaider-Beeri; Mark Woodward; Gary E Striker; Helen Vlassara
Journal: Proc Natl Acad Sci U S A Date: 2014-02-24 Impact factor: 11.205

6. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.

Authors: Andrew Folick; Holly D Oakley; Yong Yu; Eric H Armstrong; Manju Kumari; Lucas Sanor; David D Moore; Eric A Ortlund; Rudolf Zechner; Meng C Wang
Journal: Science Date: 2015-01-02 Impact factor: 47.728

Review 7. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

Authors: Maria M Mihaylova; Reuben J Shaw
Journal: Nat Cell Biol Date: 2011-09-02 Impact factor: 28.824

Review 8. Autophagy and aging.

Authors: David C Rubinsztein; Guillermo Mariño; Guido Kroemer
Journal: Cell Date: 2011-09-02 Impact factor: 41.582

9. Autophagy maintains the metabolism and function of young and old stem cells.

Authors: Theodore T Ho; Matthew R Warr; Emmalee R Adelman; Olivia M Lansinger; Johanna Flach; Evgenia V Verovskaya; Maria E Figueroa; Emmanuelle Passegué
Journal: Nature Date: 2017-03-01 Impact factor: 49.962

Review 10. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Authors: Rute Martins; Gordon J Lithgow; Wolfgang Link
Journal: Aging Cell Date: 2015-12-08 Impact factor: 9.304

11 in total

Review 1. Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer.

Authors: Hang Yang; Bin Wei; Bing Hu
Journal: Inflamm Res Date: 2021-09-21 Impact factor: 4.575

2. DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter.

Authors: Congrong Wang; Michelle Plusquin; Akram Ghantous; Zdenko Herceg; Rossella Alfano; Bianca Cox; Tim S Nawrot
Journal: Environ Health Date: 2020-12-07 Impact factor: 5.984

3. Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors.

Authors: Karamat Mohammad; Vladimir I Titorenko
Journal: Oncotarget Date: 2021-03-30

Cellular Metabolism and Aging.

1. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Review 2. Proteostasis and aging of stem cells.

Review 3. Essential role for autophagy in life span extension.

Review 4. Autophagy at the crossroads of catabolism and anabolism.

5. Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

6. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.

Review 7. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

Review 8. Autophagy and aging.

9. Autophagy maintains the metabolism and function of young and old stem cells.

Review 10. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Review 1. Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer.

2. DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter.

3. Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors.

4. Tissue-Specific Landscape of Metabolic Dysregulation during Ageing.

5. Transcriptomic analysis of elderly women with low muscle mass: association with immune system pathway.

Review 6. Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting.

7. Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts.

Review 8. The Role of SIRT3 in Exercise and Aging.

Review 9. Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance.

10. Why is delirium more frequent in the elderly?