Muhammad G Saleh1,2, Jamie Near3, Alqadafi Alhamud4, Frances Robertson4, André J W van der Kouwe5, Ernesta M Meintjes4. 1. MRC/UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Cape Town, Western Cape, South Africa. mgsaleh7@gmail.com. 2. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA. mgsaleh7@gmail.com. 3. Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada. 4. MRC/UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Cape Town, Western Cape, South Africa. 5. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Abstract
OBJECTIVE: Measuring the pure form of GABA has become increasingly important because of its association with behaviour and certain pathologies. The aim of this study was to assess the reproducibility of GABA measurements using a shim and motion navigated MEGA-SPECIAL sequence with LCModel, jMRUI and GANNET software. MATERIALS AND METHODS: Motion and shim navigated MEGA-SPECIAL scans were acquired in 20 healthy subjects. Two acquisitions were performed for each of two regions: the anterior cingulate (ACC) and medial-parietal (PAR) cortices. Absolute GABA concentration ([Formula: see text]) and GABA-to-Creatine ratio (GABA/Cr) were quantified using the three software packages. RESULTS: Using the within-subject coefficient of variation (CVws) as an index, reproducibility for both GABAH20 and GABA/Cr ranged from 13 to 22 % in the ACC and 13 to 18 % in PAR using the three software packages. CONCLUSION: Based on CVws, GABA concentrations in both the ACC and PAR are reproducible using a shim and motion navigated MEGA-SPECIAL sequence with any of the three software packages, thus demonstrating the ability to quantify the pure form of GABA using these software in studies relating GABA to pathology and healthy behaviour.
OBJECTIVE: Measuring the pure form of GABA has become increasingly important because of its association with behaviour and certain pathologies. The aim of this study was to assess the reproducibility of GABA measurements using a shim and motion navigated MEGA-SPECIAL sequence with LCModel, jMRUI and GANNET software. MATERIALS AND METHODS: Motion and shim navigated MEGA-SPECIAL scans were acquired in 20 healthy subjects. Two acquisitions were performed for each of two regions: the anterior cingulate (ACC) and medial-parietal (PAR) cortices. Absolute GABA concentration ([Formula: see text]) and GABA-to-Creatine ratio (GABA/Cr) were quantified using the three software packages. RESULTS: Using the within-subject coefficient of variation (CVws) as an index, reproducibility for both GABAH20 and GABA/Cr ranged from 13 to 22 % in the ACC and 13 to 18 % in PAR using the three software packages. CONCLUSION: Based on CVws, GABA concentrations in both the ACC and PAR are reproducible using a shim and motion navigated MEGA-SPECIAL sequence with any of the three software packages, thus demonstrating the ability to quantify the pure form of GABA using these software in studies relating GABA to pathology and healthy behaviour.
Entities:
Keywords:
1H-MRS; Edited GABA analysis; GABA; Magnetic field correction; Motion correction
Authors: Charles Gasparovic; Tao Song; Deidre Devier; H Jeremy Bockholt; Arvind Caprihan; Paul G Mullins; Stefan Posse; Rex E Jung; Leslie A Morrison Journal: Magn Reson Med Date: 2006-06 Impact factor: 4.668
Authors: Aaron T Hess; Sandra W Jacobson; Joseph L Jacobson; Christopher D Molteno; André J W van der Kouwe; Ernesta M Meintjes Journal: Metab Brain Dis Date: 2014-02-02 Impact factor: 3.584
Authors: Constantinus F Buckens; Pim A de Jong; Christian Mol; Eric Bakker; Hein P Stallman; Willem P Mali; Yolanda van der Graaf; Helena M Verkooijen Journal: PLoS One Date: 2013-08-05 Impact factor: 3.240
Authors: Yue Zhang; Edward Taub; Nouha Salibi; Gitendra Uswatte; Andrew A Maudsley; Sulaiman Sheriff; Brent Womble; Victor W Mark; David C Knight Journal: NMR Biomed Date: 2018-02-13 Impact factor: 4.044
Authors: M G Saleh; A Papantoni; M Mikkelsen; S C N Hui; G Oeltzschner; N A Puts; R A E Edden; S Carnell Journal: AJNR Am J Neuroradiol Date: 2020-05-07 Impact factor: 3.825
Authors: Muhammad G Saleh; Daniel Rimbault; Mark Mikkelsen; Georg Oeltzschner; Anna M Wang; Dengrong Jiang; Ali Alhamud; Jamie Near; Michael Schär; Ralph Noeske; James B Murdoch; Lars Ersland; Alexander R Craven; Gerard Eric Dwyer; Eli Renate Grüner; Li Pan; Sinyeob Ahn; Richard A E Edden Journal: Neuroimage Date: 2019-01-22 Impact factor: 6.556
Authors: Arjan D Hendriks; Alessio Fracasso; Catalina S Arteaga de Castro; Mark W J M Gosselink; Peter R Luijten; Natalia Petridou; Dennis W J Klomp Journal: NMR Biomed Date: 2018-02-14 Impact factor: 4.044
Authors: Eva Heckova; Michal Považan; Bernhard Strasser; Stanislav Motyka; Gilbert Hangel; Lukas Hingerl; Philipp Moser; Alexandra Lipka; Stephan Gruber; Siegfried Trattnig; Wolfgang Bogner Journal: Magn Reson Med Date: 2019-08-08 Impact factor: 4.668