Literature DB >> 27389825

Independent and core pathways in oncogenic KRAS signaling.

Ruth Nussinov1,2, Chung-Jung Tsai1, Hyunbum Jang1.   

Abstract

Entities:  

Keywords:  K-Ras4B; KRAS; PI3K; Raf; Ras effectors; Ras isoforms; Ras pathways; cell cycle; lung cancer; pancreatic cancer

Mesh：

Substances：

Year:  2016        PMID： 27389825      PMCID： PMC5003619          DOI： 10.1080/14789450.2016.1209417

Source DB:  PubMed          Journal:  Expert Rev Proteomics        ISSN： 1478-9450            Impact factor:   3.940


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  86 in total

Review 1.  RAS and RHO GTPases in G1-phase cell-cycle regulation.

Authors:  Mathew L Coleman; Christopher J Marshall; Michael F Olson
Journal:  Nat Rev Mol Cell Biol       Date:  2004-05       Impact factor: 94.444

2.  The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers.

Authors:  Elizaveta A Kovrigina; Azamat R Galiakhmetov; Evgenii L Kovrigin
Journal:  Biophys J       Date:  2015-09-01       Impact factor: 4.033

3.  NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation.

Authors:  Roopa Thapar; Jason G Williams; Sharon L Campbell
Journal:  J Mol Biol       Date:  2004-11-05       Impact factor: 5.469

Review 4.  Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications.

Authors:  Toshiro Sato; Hans Clevers
Journal:  Science       Date:  2013-06-07       Impact factor: 47.728

Review 5.  Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation.

Authors:  Ruth Nussinov; Chung-Jung Tsai; Hyunbum Jang; Tamás Korcsmáros; Peter Csermely
Journal:  Semin Cell Dev Biol       Date:  2016-04-04       Impact factor: 7.727

6.  Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway.

Authors:  Bhuvaneswari Ramaswamy; Yuanzhi Lu; Kun-Yu Teng; Gerard Nuovo; Xiaobai Li; Charles L Shapiro; Sarmila Majumder
Journal:  Cancer Res       Date:  2012-08-08       Impact factor: 12.701

7.  K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Authors:  Frederick D Tsai; Mathew S Lopes; Mo Zhou; Helen Court; Odis Ponce; James J Fiordalisi; Jessica J Gierut; Adrienne D Cox; Kevin M Haigis; Mark R Philips
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-05       Impact factor: 11.205

Review 8.  The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.

Authors:  Xaralabos Varelas
Journal:  Development       Date:  2014-04       Impact factor: 6.868

9.  Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry.

Authors:  Blair W Benham-Pyle; Beth L Pruitt; W James Nelson
Journal:  Science       Date:  2015-05-29       Impact factor: 47.728

Review 10.  The structural network of inflammation and cancer: merits and challenges.

Authors:  Emine Guven Maiorov; Ozlem Keskin; Attila Gursoy; Ruth Nussinov
Journal:  Semin Cancer Biol       Date:  2013-05-24       Impact factor: 15.707
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  7 in total

1.  The structural basis for Ras activation of PI3Kα lipid kinase.

Authors:  Mingzhen Zhang; Hyunbum Jang; Ruth Nussinov
Journal:  Phys Chem Chem Phys       Date:  2019-06-05       Impact factor: 3.676

2.  The dynamic mechanism of RASSF5 and MST kinase activation by Ras.

Authors:  Tsung-Jen Liao; Hyunbum Jang; Chung-Jung Tsai; David Fushman; Ruth Nussinov
Journal:  Phys Chem Chem Phys       Date:  2017-03-01       Impact factor: 3.676

3.  MicroRNA Expression and Correlation with mRNA Levels of Colorectal Cancer-Related Genes.

Authors:  Farahnaz Moghadamnia; Pegah Ghoraeian; Sara Minaeian; Atefeh Talebi; Farnaz Farsi; Abolfazl Akbari
Journal:  J Gastrointest Cancer       Date:  2020-03

Review 4.  A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.

Authors:  Ruth Nussinov; Chung-Jung Tsai; Hyunbum Jang
Journal:  Trends Pharmacol Sci       Date:  2017-02-27       Impact factor: 14.819

Review 5.  Calmodulin and PI3K Signaling in KRAS Cancers.

Authors:  Ruth Nussinov; Guanqiao Wang; Chung-Jung Tsai; Hyunbum Jang; Shaoyong Lu; Avik Banerjee; Jian Zhang; Vadim Gaponenko
Journal:  Trends Cancer       Date:  2017-02-18

Review 6.  Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention.

Authors:  Ruth Nussinov; Mingzhen Zhang; Chung-Jung Tsai; Tsung-Jen Liao; David Fushman; Hyunbum Jang
Journal:  Biophys Rev       Date:  2018-09-29

7.  Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.

Authors:  Duan Ni; Kun Song; Jian Zhang; Shaoyong Lu
Journal:  Int J Mol Sci       Date:  2017-10-26       Impact factor: 5.923
  7 in total

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