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Literature DB >> 2738901

Dominantly inherited cleft lip and palate in two families.

K Temple¹, M Calvert, D Plint, E Thompson, M Pembrey.

Abstract

Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.

Entities: Disease

Mesh：

Year: 1989 PMID： 2738901 PMCID： PMC1015624 DOI： 10.1136/jmg.26.6.386

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

6 in total

1. A genetic study of cleft lip and palate in Utah.

Authors: C M WOOLF; R M WOOLF; T R BROADBENT
Journal: Am J Hum Genet Date: 1963-06 Impact factor: 11.025

2. Congenital cleft lip. A genetic study of 496 propositi.

Authors: C M Woolf
Journal: J Med Genet Date: 1971-03 Impact factor: 6.318

3. The Van der Woude syndrome (dominantly inherited lip pits and clefts).

Authors: A Schinzel; M Kläusler
Journal: J Med Genet Date: 1986-08 Impact factor: 6.318

4. Suggestion of linkage of a major locus for nonsyndromic orofacial cleft with F13A and tentative assignment to chromosome 6.

Authors: H Eiberg; D Bixler; L S Nielsen; P M Conneally; J Mohr
Journal: Clin Genet Date: 1987-08 Impact factor: 4.438

5. Cleft lip+/-cleft palate: an overview of the literature and an analysis of Danish cases born between 1941 and 1968.

Authors: M Melnick; D Bixler; P Fogh-Andersen; P M Conneally
Journal: Am J Med Genet Date: 1980

6. A three generation family study of cleft lip with or without cleft palate.

Authors: C O Carter; K Evans; R Coffey; J A Roberts; A Buck; M F Roberts
Journal: J Med Genet Date: 1982-08 Impact factor: 6.318

6 in total

10 in total

1. Dominantly inherited cleft lip and palate.

Authors: J T Hecht
Journal: J Med Genet Date: 1990-09 Impact factor: 6.318

2. Van der Woude syndrome and nonsyndromic cleft lip and palate.

Authors: J T Hecht; Y Wang; S H Blanton; S P Daiger
Journal: Am J Hum Genet Date: 1992-08 Impact factor: 11.025

3. Cleft lip and palate: no evidence of linkage to transforming growth factor alpha.

Authors: J T Hecht; Y P Wang; S H Blanton; V V Michels; S P Daiger
Journal: Am J Hum Genet Date: 1991-09 Impact factor: 11.025

4. Complex segregation analysis of nonsyndromic cleft lip and palate.

Authors: J T Hecht; P Yang; V V Michels; K H Buetow
Journal: Am J Hum Genet Date: 1991-09 Impact factor: 11.025

5. Nonsyndromic cleft lip and palate: evidence of linkage to a microsatellite marker on 6p23.

Authors: F Carinci; F Pezzetti; L Scapoli; E Padula; U Baciliero; C Curioni; M Tognon
Journal: Am J Hum Genet Date: 1995-01 Impact factor: 11.025

6. No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate.

Authors: G M Vintiner; S E Holder; R M Winter; S Malcolm
Journal: J Med Genet Date: 1992-06 Impact factor: 6.318