Literature DB >> 1679292

Cleft lip and palate: no evidence of linkage to transforming growth factor alpha.

J T Hecht1, Y P Wang, S H Blanton, V V Michels, S P Daiger.   

Abstract

Recently, an association of a specific transforming growth factor alpha (TGFA) haplotype has been reported to occur in patients with nonsyndromic cleft lip and palate (CLP) who had a positive family history of the disorder. We tested linkage of CLP to TGFA in 12 multiplex families with clefting. TGFA haplotypes were constructed on the basis of three polymorphic restriction sites. No haplotype was associated with CLP, and discordant inheritance of TGFA haplotypes was observed in a single informative family. The log odds (LOD) score was -2.1 at theta = .05. These findings indicate that CLP and TGFA are not tightly linked in these families.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1679292      PMCID： PMC1683150     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  Dominantly inherited cleft lip and palate.

Authors:  J T Hecht
Journal:  J Med Genet       Date:  1990-09       Impact factor: 6.318

2.  Dominantly inherited cleft lip and palate.

Authors:  A De Paepe
Journal:  J Med Genet       Date:  1989-12       Impact factor: 6.318

3.  Complex segregation analysis of nonsyndromic cleft lip and palate.

Authors:  J T Hecht; P Yang; V V Michels; K H Buetow
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

4.  Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate.

Authors:  H H Ardinger; K H Buetow; G I Bell; J Bardach; D R VanDemark; J C Murray
Journal:  Am J Hum Genet       Date:  1989-09       Impact factor: 11.025

5.  A Taq I polymorphism for the human transforming growth factor alpha gene (TGFA).

Authors:  N K Hayward; D J Nancarrow; G I Bell
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

Review 6.  Genetics of common single malformations.

Authors:  C O Carter
Journal:  Br Med Bull       Date:  1976-01       Impact factor: 4.291

7.  Dominantly inherited cleft lip and palate in two families.

Authors:  K Temple; M Calvert; D Plint; E Thompson; M Pembrey
Journal:  J Med Genet       Date:  1989-06       Impact factor: 6.318

8.  RFLPs for epidermal growth factor (EGF), a single copy sequence at 4q25-4q27.

Authors:  J C Murray; C R DeHaven; G I Bell
Journal:  Nucleic Acids Res       Date:  1986-06-25       Impact factor: 16.971

9.  Test of genetic heterogeneity of cleft lip with or without cleft palate as related to race and severity.

Authors:  C S Chung; A M Beechert; R E Lew
Journal:  Genet Epidemiol       Date:  1989       Impact factor: 2.135

10.  Major gene determination of liability to cleft lip with or without cleft palate: a multiracial view.

Authors:  M L Marazita; M A Spence; M Melnick
Journal:  J Craniofac Genet Dev Biol Suppl       Date:  1986
View more
  27 in total

1.  Genetic variation in transforming growth factor alpha: possible association of BamHI polymorphism with bilateral sporadic cleft lip and palate.

Authors:  C Stoll; J F Qian; J Feingold; P Sauvage; E May
Journal:  Am J Hum Genet       Date:  1992-04       Impact factor: 11.025

2.  Genetics of cleft lip and palate : a review.

Authors:  Zainul Ahmad Rajion; Zilfalil Alwi
Journal:  Malays J Med Sci       Date:  2007-01

3.  Van der Woude syndrome and nonsyndromic cleft lip and palate.

Authors:  J T Hecht; Y Wang; S H Blanton; S P Daiger
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

4.  Mode of inheritance of nonsyndromic cleft lip with or without cleft palate: a reanalysis.

Authors:  L E Mitchell; N Risch
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

5.  Autosomal dominant nonsyndromic cleft lip and palate: significant evidence of linkage at 18q21.1.

Authors:  Soraya Beiraghi; Swapan K Nath; Matthew Gaines; Desh D Mandhyan; David Hutchings; Uppala Ratnamala; Ken McElreavey; Lucia Bartoloni; Gregory S Antonarakis; Stylianos E Antonarakis; Uppala Radhakrishna
Journal:  Am J Hum Genet       Date:  2007-05-18       Impact factor: 11.025

6.  Nonsyndromic cleft lip and palate: evidence of linkage to a microsatellite marker on 6p23.

Authors:  F Carinci; F Pezzetti; L Scapoli; E Padula; U Baciliero; C Curioni; M Tognon
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

7.  GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk.

Authors:  Lijia Dong; Lian Ma
Journal:  Int J Clin Exp Med       Date:  2015-03-15

8.  Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO).

Authors:  R Shiang; A C Lidral; H H Ardinger; K H Buetow; P A Romitti; R G Munger; J C Murray
Journal:  Am J Hum Genet       Date:  1993-10       Impact factor: 11.025

9.  No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate.

Authors:  G M Vintiner; S E Holder; R M Winter; S Malcolm
Journal:  J Med Genet       Date:  1992-06       Impact factor: 6.318

10.  Nonsyndromic cleft lip and palate: no evidence of linkage to HLA or factor 13A.

Authors:  J T Hecht; Y Wang; B Connor; S H Blanton; S P Daiger
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.