Patcharaporn Sudchada1,2, Spencer Laehn3. 1. Pharmaceutical Care Research Unit, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Ta-Poe, Meaung, Phitsanulok, 65000, Thailand. psudchada@gmail.com. 2. School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53702, USA. psudchada@gmail.com. 3. School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53702, USA.
Abstract
PURPOSE: The aim of the study was to summarize the evidence of the validation of CKD-EPI equation and alternative creatinine-based equations in Asian population. METHODS: Relevant validation studies of CKD-EPI and other creatinine-based equations were identified by a systematic literature searching of PubMed conducted from January 2009 through August 2014. Searching terms included "CKD EPI", "Kidney function test [MeSH] and validation", and "Glomerular filtration rate [MeSH] and validation" without language or design of study restrictions. The quality of each study was assessed using Quality Assessment of diagnostic Accuracy studies-2 tool. RESULTS: Of 1064 studies identified, 10 studies were included in the present systematically review. The CKD-EPI equation has been validated in several Asian population including Thai, Japanese, Chinese, Taiwanese, Pakistani as well as Arabic. CKD-EPI equation met the clinically significant 75 % P30 value in several populations, although corrections of some factors may increase the accuracy of the equation. However, some populations may need to find more accurate equations or methods to estimate GFR for the patients. CONCLUSIONS: CKD-EPI is a good equation to start with for estimation of patients' renal function but for certain disease states and racial populations, the CKD-EPI should be validated before applying. More research is needed in order to develop validated eGFR equations for specific populations and to improve upon the accuracies of currently acceptable equations to better guide therapy and improve patient outcomes.
PURPOSE: The aim of the study was to summarize the evidence of the validation of CKD-EPI equation and alternative creatinine-based equations in Asian population. METHODS: Relevant validation studies of CKD-EPI and other creatinine-based equations were identified by a systematic literature searching of PubMed conducted from January 2009 through August 2014. Searching terms included "CKD EPI", "Kidney function test [MeSH] and validation", and "Glomerular filtration rate [MeSH] and validation" without language or design of study restrictions. The quality of each study was assessed using Quality Assessment of diagnostic Accuracy studies-2 tool. RESULTS: Of 1064 studies identified, 10 studies were included in the present systematically review. The CKD-EPI equation has been validated in several Asian population including Thai, Japanese, Chinese, Taiwanese, Pakistani as well as Arabic. CKD-EPI equation met the clinically significant 75 % P30 value in several populations, although corrections of some factors may increase the accuracy of the equation. However, some populations may need to find more accurate equations or methods to estimate GFR for the patients. CONCLUSIONS: CKD-EPI is a good equation to start with for estimation of patients' renal function but for certain disease states and racial populations, the CKD-EPI should be validated before applying. More research is needed in order to develop validated eGFR equations for specific populations and to improve upon the accuracies of currently acceptable equations to better guide therapy and improve patient outcomes.
Authors: Saleem Jessani; Andrew S Levey; Rasool Bux; Lesley A Inker; Muhammad Islam; Nish Chaturvedi; Christophe Mariat; Christopher H Schmid; Tazeen H Jafar Journal: Am J Kidney Dis Date: 2013-09-26 Impact factor: 8.860
Authors: Andrew S Levey; Lesley A Stevens; Christopher H Schmid; Yaping Lucy Zhang; Alejandro F Castro; Harold I Feldman; John W Kusek; Paul Eggers; Frederick Van Lente; Tom Greene; Josef Coresh Journal: Ann Intern Med Date: 2009-05-05 Impact factor: 25.391
Authors: Penny F Whiting; Anne W S Rutjes; Marie E Westwood; Susan Mallett; Jonathan J Deeks; Johannes B Reitsma; Mariska M G Leeflang; Jonathan A C Sterne; Patrick M M Bossuyt Journal: Ann Intern Med Date: 2011-10-18 Impact factor: 25.391