Literature DB >> 27387794

Flipping the Switch "On" for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed!

Huy X Ngo1, Sylvie Garneau-Tsodikova2.   

Abstract

In a recent issue of Structure, Caldwell et al. (2016) determined crystal structures of APH(2″)-Ia in complex with various combinations of aminoglycosides and nucleosides, which compellingly revealed that the catalytic activity of this resistance enzyme is regulated by a conformational change of the triphosphate of GTP, a mechanism previously unknown for antibiotic kinases.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27387794      PMCID： PMC5960806          DOI： 10.1016/j.str.2016.06.006

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  11 in total

1.  Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'').

Authors:  David D Boehr; Denis M Daigle; Gerard D Wright
Journal:  Biochemistry       Date:  2004-08-03       Impact factor: 3.162

2.  Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.

Authors:  Shane J Caldwell; Albert M Berghuis
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

3.  Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia.

Authors:  Shane J Caldwell; Yue Huang; Albert M Berghuis
Journal:  Structure       Date:  2016-05-05       Impact factor: 5.006

4.  Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.

Authors:  J J Ferretti; K S Gilmore; P Courvalin
Journal:  J Bacteriol       Date:  1986-08       Impact factor: 3.490

5.  Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives.

Authors:  Sylvie Garneau-Tsodikova; Kristin J Labby
Journal:  Medchemcomm       Date:  2015-09-21       Impact factor: 3.597

6.  Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages.

Authors:  Torill C S Rosvoll; Belinda L Lindstad; Tracy M Lunde; Kristin Hegstad; Bettina Aasnaes; Anette M Hammerum; Camilla H Lester; Gunnar S Simonsen; Arnfinn Sundsfjord; Torunn Pedersen
Journal:  FEMS Immunol Med Microbiol       Date:  2012-06-27

7.  Aminoglycoside antibiotic phosphotransferases are also serine protein kinases.

Authors:  D M Daigle; G A McKay; P R Thompson; G D Wright
Journal:  Chem Biol       Date:  1999-01

8.  Mechanisms of gentamicin resistance in Staphylococcus aureus.

Authors:  J E Dowding
Journal:  Antimicrob Agents Chemother       Date:  1977-01       Impact factor: 5.191

9.  Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides.

Authors:  Keith D Green; Wenjing Chen; Jacob L Houghton; Micha Fridman; Sylvie Garneau-Tsodikova
Journal:  Chembiochem       Date:  2010-01-04       Impact factor: 3.164

10.  Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme.

Authors:  Hilary Frase; Marta Toth; Sergei B Vakulenko
Journal:  J Biol Chem       Date:  2012-10-31       Impact factor: 5.157
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  2 in total

Review 1.  Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Chem Soc Rev       Date:  2018-02-19       Impact factor: 54.564

2.  Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside-2''-phosphotransferases.

Authors:  Clyde A Smith; Marta Toth; Nichole K Stewart; Lauren Maltz; Sergei B Vakulenko
Journal:  Acta Crystallogr D Struct Biol       Date:  2019-11-29       Impact factor: 7.652
  2 in total

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