Elif Baysal1, Secaattin Gulsen2, Ismail Aytac3, Fatih Celenk4, Nuray Ensari5, Seyithan Taysi6, Habib Binici7, Cengiz Durucu4, Semih Mumbuc4, Muzaffer Kanlikama4. 1. a Faculty of Medicine, Otolaryngology Department , Inonu University , Malatya , Turkey. 2. b Ersin Aslan State Hospital , Gaziantep , Turkey. 3. c Midyat State Hospital , Mardin , Turkey. 4. d Faculty of Medicine, Otolaryngology Department , Gaziantep University , Gaziantep , Turkey. 5. e Antalya Education and Research Hospital , Antalya , Turkey. 6. f Faculty of Medicine, Biochemistry Department , Gaziantep University , Gaziantep , Turkey. 7. g Faculty of Medicine, Otolaryngology Department , Harran University , Sanliurfa , Turkey.
Abstract
OBJECTIVES: Otosclerosis is a disease involving abnormal bone turnover in the human otic capsule that results in hearing loss. Several hypotheses have been suggested for the etiopathogenesis of otosclerosis; however, its etiology remains unclear. METHODS: This study evaluated the correlation between otosclerosis and levels of paraoxonase-1 (PON1), arylesterase, total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), total sulfhydryl (-SH) groups, lipid hydroperoxide, and ceruloplasmin in the serum of otosclerosis patients and healthy subjects with respect to oxidative stress. RESULTS: In our study, TOS and OSI levels were higher in the otosclerosis patients than in the controls. The PON1 levels showed that oxidative stress was severe, and as a result, antioxidants were consumed and depleted. DISCUSSION: When an imbalance between oxygen free radical production and antioxidative defense mechanisms occurs, reactive oxygen species levels may increase, which in turn may damage cells and tissues through the peroxidation of phospholipid membrane structures. The body initially responds with increased antioxidant production, but if the oxidative stress is severe, decreased antioxidant levels may result. This study reports expression levels of oxidative stress species in otosclerosis patients.
OBJECTIVES:Otosclerosis is a disease involving abnormal bone turnover in the human otic capsule that results in hearing loss. Several hypotheses have been suggested for the etiopathogenesis of otosclerosis; however, its etiology remains unclear. METHODS: This study evaluated the correlation between otosclerosis and levels of paraoxonase-1 (PON1), arylesterase, total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), total sulfhydryl (-SH) groups, lipid hydroperoxide, and ceruloplasmin in the serum of otosclerosispatients and healthy subjects with respect to oxidative stress. RESULTS: In our study, TOS and OSI levels were higher in the otosclerosispatients than in the controls. The PON1 levels showed that oxidative stress was severe, and as a result, antioxidants were consumed and depleted. DISCUSSION: When an imbalance between oxygen free radical production and antioxidative defense mechanisms occurs, reactive oxygen species levels may increase, which in turn may damage cells and tissues through the peroxidation of phospholipid membrane structures. The body initially responds with increased antioxidant production, but if the oxidative stress is severe, decreased antioxidant levels may result. This study reports expression levels of oxidative stress species in otosclerosispatients.
Authors: Mehmet Aslan; Mustafa Kosecik; Mehmet Horoz; Sahbettin Selek; Hakim Celik; Ozcan Erel Journal: Atherosclerosis Date: 2006-05-08 Impact factor: 5.162
Authors: Lorena Franco-Martinez; Diego Romero; José A García-Navarro; Fernando Tecles; Mariana Teles; Asta Tvarijonaviciute Journal: Environ Sci Pollut Res Int Date: 2016-10-01 Impact factor: 4.223