Suat Zengin1, Behcet A1, Sahin Karta2, Basri Can1, Mustafa Orkmez3, Abdullah Taskin4, Ugur Lok5, Bediha Gulen6, Cuma Yildirim1, Seyithan Taysi3. 1. Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey. 2. Department of Emergency Medicine, ¦ehitkamil State Hospital, Gaziantep, Turkey. 3. Medical Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey. 4. Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey. 5. Department of Emergency Medicine, Adiyaman University, Adiyaman, Turkey. 6. Department of Emergency Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Abstract
BACKGROUND: Carbon monoxide poisoning (COP) is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase (PON), arylesterase (ARYL), ceruloplasmin (Cp), and sulfhydryl (-SH) in the treatment of COP, and to further understand the pathophysiology of COP. METHODS: This prospective study comprised 107 individuals with COP (group 1) and 50 healthy volunteers (group 2). Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90(th) and 180(th) minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and -SH were measured in both groups. RESULTS: Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and -SH levels. PON, ARYL, and -SH levels were significantly decreased in group 1 compared with group 2. Conversely, Cp was significantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90(th) and 180(th) minutes (P<0.001), Cp was higher on admission than at the other time points (P<0.001). CONCLUSIONS: Participants with COP had decreased levels of antioxidants (PON, ARLY, and -SH). COP represses the antioxidant system.
BACKGROUND:Carbon monoxidepoisoning (COP) is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase (PON), arylesterase (ARYL), ceruloplasmin (Cp), and sulfhydryl (-SH) in the treatment of COP, and to further understand the pathophysiology of COP. METHODS: This prospective study comprised 107 individuals with COP (group 1) and 50 healthy volunteers (group 2). Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90(th) and 180(th) minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and -SH were measured in both groups. RESULTS: Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and -SH levels. PON, ARYL, and -SH levels were significantly decreased in group 1 compared with group 2. Conversely, Cp was significantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90(th) and 180(th) minutes (P<0.001), Cp was higher on admission than at the other time points (P<0.001). CONCLUSIONS:Participants with COP had decreased levels of antioxidants (PON, ARLY, and -SH). COP represses the antioxidant system.
Entities:
Keywords:
Arylesterase; Carbon monoxide poisoning; Ceruloplasmin; Paraoxonase; Total sulfhydryl groups
Authors: Mehmet Horoz; Mehmet Aslan; Sahbettin Selek; Ahmet O Koylu; Cengiz Bolukbas; Filiz F Bolukbas; Hakim Celik; Ozcan Erel Journal: Clin Biochem Date: 2007-02-03 Impact factor: 3.281
Authors: Crina Claudia Rusu; Simona Racasan; Ina Maria Kacso; Diana Moldovan; Alina Potra; Ioan Mihai Patiu; Dan Vladutiu; Mirela Gherman Caprioara Journal: Clujul Med Date: 2016-04-15