| Literature DB >> 2738663 |
J R Grierson1, J M Link, C A Mathis, J S Rasey, K A Krohn.
Abstract
A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F] fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca) of greater than 650 Ci/mmol (EOB) and a synthesis time of approximately 140 min. The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin.Entities:
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Year: 1989 PMID： 2738663
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057