Literature DB >> 32506448

Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue.

Inna Gertsenshteyn1,2,3, Mihai Giurcanu4, Peter Vaupel5,6, Howard Halpern2,3.   

Abstract

Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen ( P O 2 ) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of P O 2  ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies.
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.

Entities:  

Keywords:  electron paramagnetic resonance; hypoxia; oxygen sensing

Mesh：

Substances：

Year:  2020        PMID： 32506448      PMCID： PMC7719598          DOI： 10.1113/JP278816

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  52 in total

1.  Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents.

Authors:  R D Braun; J L Lanzen; S A Snyder; M W Dewhirst
Journal:  Am J Physiol Heart Circ Physiol       Date:  2001-06       Impact factor: 4.733

2.  Physical and chemical mechanisms in the injury of cells of ionizing radiations.

Authors:  P HOWARD-FLANDERS
Journal:  Adv Biol Med Phys       Date:  1958

3.  Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

Authors:  P Vaupel; K Schlenger; C Knoop; M Höckel
Journal:  Cancer Res       Date:  1991-06-15       Impact factor: 12.701

4.  Where it's at really matters: in situ in vivo vascular endothelial growth factor spatially correlates with electron paramagnetic resonance pO2 images in tumors of living mice.

Authors:  Martyna Elas; Danielle Hleihel; Eugene D Barth; Chad R Haney; Kang-Hyun Ahn; Charles A Pelizzari; Boris Epel; Ralph R Weichselbaum; Howard J Halpern
Journal:  Mol Imaging Biol       Date:  2011-12       Impact factor: 3.488

Review 5.  Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.

Authors:  H Maeda; J Wu; T Sawa; Y Matsumura; K Hori
Journal:  J Control Release       Date:  2000-03-01       Impact factor: 9.776

6.  A comparative study of the hypoxia PET tracers [¹⁸F]HX4, [¹⁸F]FAZA, and [¹⁸F]FMISO in a preclinical tumor model.

Authors:  Sarah G J A Peeters; Catharina M L Zegers; Natasja G Lieuwes; Wouter van Elmpt; Jonas Eriksson; Guus A M S van Dongen; Ludwig Dubois; Philippe Lambin
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-12-06       Impact factor: 7.038

7.  Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

Authors:  M Höckel; K Schlenger; C Knoop; P Vaupel
Journal:  Cancer Res       Date:  1991-11-15       Impact factor: 12.701

Review 8.  Detection and characterization of tumor hypoxia using pO2 histography.

Authors:  Peter Vaupel; Michael Höckel; Arnulf Mayer
Journal:  Antioxid Redox Signal       Date:  2007-08       Impact factor: 8.401

Review 9.  Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications.

Authors:  Bernard Gallez; Christine Baudelet; Bénédicte F Jordan
Journal:  NMR Biomed       Date:  2004-08       Impact factor: 4.044

10.  The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites.

Authors:  Yukiko Masaki; Yoichi Shimizu; Takeshi Yoshioka; Yukari Tanaka; Ken-Ichi Nishijima; Songji Zhao; Kenichi Higashino; Shingo Sakamoto; Yoshito Numata; Yoshitaka Yamaguchi; Nagara Tamaki; Yuji Kuge
Journal:  Sci Rep       Date:  2015-11-19       Impact factor: 4.379
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  6 in total

1.  The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth.

Authors:  Inna Gertsenshteyn; Boris Epel; Amandeep Ahluwalia; Heejong Kim; Xiaobing Fan; Eugene Barth; Marta Zamora; Erica Markiewicz; Hsiu-Ming Tsai; Subramanian Sundramoorthy; Lara Leoni; John Lukens; Mohammed Bhuiyan; Richard Freifelder; Anna Kucharski; Mihai Giurcanu; Brian B Roman; Gregory Karczmar; Chien-Min Kao; Howard Halpern; Chin-Tu Chen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2022-07-06       Impact factor: 10.057

2.  Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images.

Authors:  Inna Gertsenshteyn; Boris Epel; Eugene Barth; Lara Leoni; Erica Markiewicz; Hsiu-Ming Tsai; Xiaobing Fan; Mihai Giurcanu; Darwin Bodero; Marta Zamora; Subramanian Sundramoorthy; Heejong Kim; Richard Freifelder; Mohammed Bhuiyan; Anna Kucharski; Gregory Karczmar; Chien-Min Kao; Howard Halpern; Chin-Tu Chen
Journal:  Radiol Imaging Cancer       Date:  2021-03-26

Review 3.  Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies.

Authors:  Raefa Abou Khouzam; Klaudia Brodaczewska; Aleksandra Filipiak; Nagwa Ahmed Zeinelabdin; Stephanie Buart; Cezary Szczylik; Claudine Kieda; Salem Chouaib
Journal:  Front Immunol       Date:  2021-01-20       Impact factor: 7.561

Review 4.  Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances.

Authors:  Inês Godet; Steven Doctorman; Fan Wu; Daniele M Gilkes
Journal:  Cells       Date:  2022-02-16       Impact factor: 6.600

5.  Investigation of energy metabolic dynamism in hyperthermia-resistant ovarian and uterine cancer cells under heat stress.

Authors:  Taisei Kanamori; Natumi Miyazaki; Shigeki Aoki; Kousei Ito; Akihiro Hisaka; Hiroto Hatakeyama
Journal:  Sci Rep       Date:  2021-07-19       Impact factor: 4.379

6.  Large-scale synthesis of a monophosphonated tetrathiatriarylmethyl spin probe for concurrent in vivo measurement of pO2, pH and inorganic phosphate by EPR.

Authors:  Teresa D Gluth; Martin Poncelet; Stephen DeVience; Marieta Gencheva; Emily H Hoblitzell; Valery V Khramtsov; Timothy D Eubank; Benoit Driesschaert
Journal:  RSC Adv       Date:  2021-07-27       Impact factor: 4.036
  6 in total

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