Eri Miyamoto-Mikami1, Haruka Murakami2, Hiroyasu Tsuchie3, Hideyuki Takahashi4, Nao Ohiwa4, Motohiko Miyachi2, Takashi Kawahara5, Noriyuki Fuku6. 1. Japan Society for the Promotion of Science, Japan; Department of Sports and Life Science, National Institute of Fitness and Sports in Kanoya, Japan. 2. Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Japan. 3. Faculty of Law, Toyo University, Japan. 4. Department of Sports Science, Japan Institute of Sports Sciences, Japan. 5. Medical Center, Japan Institute of Sports Sciences, Japan. 6. Graduate School of Health and Sports Science, Juntendo University, Japan. Electronic address: noriyuki.fuku@nifty.com.
Abstract
OBJECTIVES: This study aimed to examine the association between a total genotype score (TGS) based on previously published genetic polymorphism candidates and differences in sprint/power performance. DESIGN: Case-control association study. METHODS: We analysed 21 polymorphisms, which have previously been associated with sprint/power performance and related phenotypes, in 211 Japanese sprint/power track and field athletes (77 regional, 72 national, and 62 international athletes) and 649 Japanese controls using the TaqMan SNP genotyping assay. We calculated the TGS (maximum value of 100 for the theoretically optimal polygenic score) for the 21 polymorphisms. RESULTS: All groups exhibited similar TGSs (control: 55.9±7.2, regional: 55.1±7.1, national: 56.1±7.4, and international: 56.0±7.8, p=0.827 by one-way analysis of variance). Nine of the 21 polymorphisms had the same direction of effect (odds ratio >1.0) as in previous studies, while 12 had the opposite direction of effect (odds ratio <1.0). Three polymorphisms (rs699 in AGT, rs41274853 in CNTFR, and rs7832552 in TRHR), which had the same direction of effect as in previous studies, were associated with international sprint/power athlete status (p<0.05). However, after multiple testing corrections, the statistical significance of these polymorphisms was not retained. CONCLUSIONS: These results suggest that TGSs based on the 21 previously published sprint/power performance-associated polymorphisms did not influence the sprint/power athlete status of Japanese track and field athletes. However, our results maintain the possibility that three of these polymorphisms might be associated with sprint/power performance.
OBJECTIVES: This study aimed to examine the association between a total genotype score (TGS) based on previously published genetic polymorphism candidates and differences in sprint/power performance. DESIGN: Case-control association study. METHODS: We analysed 21 polymorphisms, which have previously been associated with sprint/power performance and related phenotypes, in 211 Japanese sprint/power track and field athletes (77 regional, 72 national, and 62 international athletes) and 649 Japanese controls using the TaqMan SNP genotyping assay. We calculated the TGS (maximum value of 100 for the theoretically optimal polygenic score) for the 21 polymorphisms. RESULTS: All groups exhibited similar TGSs (control: 55.9±7.2, regional: 55.1±7.1, national: 56.1±7.4, and international: 56.0±7.8, p=0.827 by one-way analysis of variance). Nine of the 21 polymorphisms had the same direction of effect (odds ratio >1.0) as in previous studies, while 12 had the opposite direction of effect (odds ratio <1.0). Three polymorphisms (rs699 in AGT, rs41274853 in CNTFR, and rs7832552 in TRHR), which had the same direction of effect as in previous studies, were associated with international sprint/power athlete status (p<0.05). However, after multiple testing corrections, the statistical significance of these polymorphisms was not retained. CONCLUSIONS: These results suggest that TGSs based on the 21 previously published sprint/power performance-associated polymorphisms did not influence the sprint/power athlete status of Japanese track and field athletes. However, our results maintain the possibility that three of these polymorphisms might be associated with sprint/power performance.
Authors: Praval Khanal; Lingxiao He; Adam J Herbert; Georgina K Stebbings; Gladys L Onambele-Pearson; Hans Degens; Christopher I Morse; Martine Thomis; Alun G Williams Journal: Genes (Basel) Date: 2020-12-05 Impact factor: 4.096
Authors: Mika Saito; Michał Ginszt; Ekaterina A Semenova; Myosotis Massidda; Kinga Huminska-Lisowska; Monika Michałowska-Sawczyn; Hiroki Homma; Paweł Cięszczyk; Takanobu Okamoto; Andrey K Larin; Edward V Generozov; Piotr Majcher; Koichi Nakazato; Ildus I Ahmetov; Naoki Kikuchi Journal: Biol Sport Date: 2021-11-10 Impact factor: 4.606