Sana Parsian1, Nadia V Giannakopoulos2, Habib Rahbar3, Mara H Rendi4, Xiaoyu Chai5, Savannah C Partridge6. 1. Department of Radiology, Seattle Cancer Care Alliance, University of Washington School of Medicine, 825 Eastlake Ave. E., G3-200, Seattle, WA 98109-1023, USA. Electronic address: parsian@uw.edu. 2. Department of Anatomic Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356100, Seattle, WA 98195, USA. Electronic address: ngiannak@ualberta.ca. 3. Department of Radiology, Seattle Cancer Care Alliance, University of Washington School of Medicine, 825 Eastlake Ave. E., G3-200, Seattle, WA 98109-1023, USA. Electronic address: hrahbar@uw.edu. 4. Department of Anatomic Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356100, Seattle, WA 98195, USA. Electronic address: mararend@uw.edu. 5. Department of Biostatistics & Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2-B500, Seattle, WA 98109, USA. Electronic address: xchai@fredhutch.org. 6. Department of Radiology, Seattle Cancer Care Alliance, University of Washington School of Medicine, 825 Eastlake Ave. E., G3-200, Seattle, WA 98109-1023, USA. Electronic address: scp3@u.washington.edu.
Abstract
OBJECTIVE: To determine the underlying histopathologic features influencing apparent diffusion coefficient (ADC) values of breast fibroadenomas. MATERIALS AND METHODS: Biopsy-proven fibroadenomas (n=26) initially identified as suspicious on breast magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathologic assessments of lesion cellularity and stromal type were compared with ADC measures on diffusion-weighted MRI. RESULTS: Presence of epithelial hyperplasia (increased cellularity) and dense collagenous stroma were both significantly associated with lower lesion ADC values (P=.02 and .004, respectively). CONCLUSION: Variations in epithelial cellularity and stromal type influence breast lesion ADC values and may explain the wide range of ADC measures observed in benign fibroadenomas.
OBJECTIVE: To determine the underlying histopathologic features influencing apparent diffusion coefficient (ADC) values of breast fibroadenomas. MATERIALS AND METHODS: Biopsy-proven fibroadenomas (n=26) initially identified as suspicious on breast magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathologic assessments of lesion cellularity and stromal type were compared with ADC measures on diffusion-weighted MRI. RESULTS: Presence of epithelial hyperplasia (increased cellularity) and dense collagenous stroma were both significantly associated with lower lesion ADC values (P=.02 and .004, respectively). CONCLUSION: Variations in epithelial cellularity and stromal type influence breast lesion ADC values and may explain the wide range of ADC measures observed in benign fibroadenomas.
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