Literature DB >> 27378294

ChAsE: chromatin analysis and exploration tool.

Hamid Younesy1, Cydney B Nielsen2, Matthew C Lorincz3, Steven J M Jones4, Mohammad M Karimi5, Torsten Möller6.   

Abstract

: We present ChAsE, a cross-platform desktop application developed for interactive visualization, exploration and clustering of epigenomic data such as ChIP-seq experiments. ChAsE is designed and developed in close collaboration with several groups of biologists and bioinformaticians with a focus on usability and interactivity. Data can be analyzed through k-means clustering, specifying presence or absence of signal in epigenetic data and performing set operations between clusters. Results can be explored in an interactive heat map and profile plot interface and exported for downstream analysis or as high quality figures suitable for publications.
AVAILABILITY AND IMPLEMENTATION: Software, source code (MIT License), data and video tutorials available at http://chase.cs.univie.ac.at CONTACT: : mkarimi@brc.ubc.ca or torsten.moeller@univie.ac.atSupplementary information: Supplementary data are available at Bioinformatics online.
© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Year:  2016        PMID: 27378294      PMCID: PMC5079470          DOI: 10.1093/bioinformatics/btw382

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  9 in total

1.  Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

Authors:  Miao Yu; Gary C Hon; Keith E Szulwach; Chun-Xiao Song; Liang Zhang; Audrey Kim; Xuekun Li; Qing Dai; Yin Shen; Beomseok Park; Jung-Hyun Min; Peng Jin; Bing Ren; Chuan He
Journal:  Cell       Date:  2012-05-17       Impact factor: 41.582

2.  The Human Epigenome Browser at Washington University.

Authors:  Xin Zhou; Brett Maricque; Mingchao Xie; Daofeng Li; Vasavi Sundaram; Eric A Martin; Brian C Koebbe; Cydney Nielsen; Martin Hirst; Peggy Farnham; Robert M Kuhn; Jingchun Zhu; Ivan Smirnov; W James Kent; David Haussler; Pamela A F Madden; Joseph F Costello; Ting Wang
Journal:  Nat Methods       Date:  2011-11-29       Impact factor: 28.547

3.  DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs.

Authors:  Mohammad M Karimi; Preeti Goyal; Irina A Maksakova; Misha Bilenky; Danny Leung; Jie Xin Tang; Yoichi Shinkai; Dixie L Mager; Steven Jones; Martin Hirst; Matthew C Lorincz
Journal:  Cell Stem Cell       Date:  2011-06-03       Impact factor: 24.633

4.  Discovery and characterization of chromatin states for systematic annotation of the human genome.

Authors:  Jason Ernst; Manolis Kellis
Journal:  Nat Biotechnol       Date:  2010-07-25       Impact factor: 54.908

5.  Spark: a navigational paradigm for genomic data exploration.

Authors:  Cydney B Nielsen; Hamid Younesy; Henriette O'Geen; Xiaoqin Xu; Andrew R Jackson; Aleksandar Milosavljevic; Ting Wang; Joseph F Costello; Martin Hirst; Peggy J Farnham; Steven J M Jones
Journal:  Genome Res       Date:  2012-09-07       Impact factor: 9.043

6.  Cistrome: an integrative platform for transcriptional regulation studies.

Authors:  Tao Liu; Jorge A Ortiz; Len Taing; Clifford A Meyer; Bernett Lee; Yong Zhang; Hyunjin Shin; Swee S Wong; Jian Ma; Ying Lei; Utz J Pape; Michael Poidinger; Yiwen Chen; Kevin Yeung; Myles Brown; Yaron Turpaz; X Shirley Liu
Journal:  Genome Biol       Date:  2011-08-22       Impact factor: 13.583

7.  FindPeaks 3.1: a tool for identifying areas of enrichment from massively parallel short-read sequencing technology.

Authors:  Anthony P Fejes; Gordon Robertson; Mikhail Bilenky; Richard Varhol; Matthew Bainbridge; Steven J M Jones
Journal:  Bioinformatics       Date:  2008-07-03       Impact factor: 6.937

8.  ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome.

Authors:  Gary Hon; Bing Ren; Wei Wang
Journal:  PLoS Comput Biol       Date:  2008-10-17       Impact factor: 4.475

9.  Epiviz: interactive visual analytics for functional genomics data.

Authors:  Florin Chelaru; Llewellyn Smith; Naomi Goldstein; Héctor Corrada Bravo
Journal:  Nat Methods       Date:  2014-08-03       Impact factor: 28.547

  9 in total
  19 in total

1.  The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II.

Authors:  Marco Trizzino; Elisa Barbieri; Ana Petracovici; Shuai Wu; Sarah A Welsh; Tori A Owens; Silvia Licciulli; Rugang Zhang; Alessandro Gardini
Journal:  Cell Rep       Date:  2018-06-26       Impact factor: 9.423

2.  ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.

Authors:  Yichen Xu; Peiwei Huangyang; Ying Wang; Lingru Xue; Emily Devericks; Hao G Nguyen; Xiuyan Yu; Juan A Oses-Prieto; Alma L Burlingame; Sohit Miglani; Hani Goodarzi; Davide Ruggero
Journal:  Cell       Date:  2021-09-23       Impact factor: 66.850

3.  MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.

Authors:  Matthew L Hemming; Morgan R Benson; Michael A Loycano; Justin A Anderson; Jessica L Andersen; Madeleine L Taddei; Andrei V Krivtsov; Brandon J Aubrey; Jevon A Cutler; Charlie Hatton; Ewa Sicinska; Scott A Armstrong
Journal:  Cancer Discov       Date:  2022-07-06       Impact factor: 38.272

4.  Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Authors:  Robert N Judson; Marco Quarta; Menno J Oudhoff; Hesham Soliman; Lin Yi; Chih Kai Chang; Gloria Loi; Ryan Vander Werff; Alissa Cait; Mark Hamer; Justin Blonigan; Patrick Paine; Linda T N Doan; Elena Groppa; WenJun He; Le Su; Regan H Zhang; Peter Xu; Christine Eisner; Marcela Low; Ingrid Barta; Coral-Ann B Lewis; Colby Zaph; Mohammad M Karimi; Thomas A Rando; Fabio M Rossi
Journal:  Cell Stem Cell       Date:  2018-01-25       Impact factor: 24.633

5.  Targeted Enhancer Activation by a Subunit of the Integrator Complex.

Authors:  Elisa Barbieri; Marco Trizzino; Sarah Ann Welsh; Tori Alexandra Owens; Bruno Calabretta; Martin Carroll; Kavitha Sarma; Alessandro Gardini
Journal:  Mol Cell       Date:  2018-06-28       Impact factor: 17.970

6.  Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.

Authors:  Matthew L Hemming; Matthew A Lawlor; Rhamy Zeid; Tom Lesluyes; Jonathan A Fletcher; Chandrajit P Raut; Ewa T Sicinska; Frédéric Chibon; Scott A Armstrong; George D Demetri; James E Bradner
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-04       Impact factor: 11.205

7.  Hepatocyte Nuclear Factor 4-Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver.

Authors:  Avinash Thakur; Jasper C H Wong; Evan Y Wang; Jeremy Lotto; Donghwan Kim; Jung-Chien Cheng; Matthew Mingay; Rebecca Cullum; Vaishali Moudgil; Nafeel Ahmed; Shu-Huei Tsai; Wei Wei; Colum P Walsh; Tabea Stephan; Misha Bilenky; Bettina M Fuglerud; Mohammad M Karimi; Frank J Gonzalez; Martin Hirst; Pamela A Hoodless
Journal:  Hepatology       Date:  2019-05-15       Impact factor: 17.425

8.  NucTools: analysis of chromatin feature occupancy profiles from high-throughput sequencing data.

Authors:  Yevhen Vainshtein; Karsten Rippe; Vladimir B Teif
Journal:  BMC Genomics       Date:  2017-02-14       Impact factor: 3.969

9.  JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity.

Authors:  Dawei Huo; Hao Chen; Yiming Cheng; Xin Song; Kai Zhang; Mulin Jun Li; Chenghao Xuan
Journal:  Cell Death Differ       Date:  2019-07-29       Impact factor: 15.828

10.  The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Authors:  Akihiko Numata; Hui Si Kwok; Akira Kawasaki; Jia Li; Qi-Ling Zhou; Jon Kerry; Touati Benoukraf; Deepak Bararia; Feng Li; Erica Ballabio; Marta Tapia; Aniruddha J Deshpande; Robert S Welner; Ruud Delwel; Henry Yang; Thomas A Milne; Reshma Taneja; Daniel G Tenen
Journal:  Nat Commun       Date:  2018-04-24       Impact factor: 14.919

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