Literature DB >> 2737671

Inactivated X chromosome fold in human leukemia and related clonal disorders.

M R Avalos1, C Léonard, F Mielot, G Tchernia.   

Abstract

A disturbance of the X chromosome inactivation process has been demonstrated in some human tumors. In order to study this phenomenon in leukemia, the site of unusually frequent folding in Xq13-q21 was used as a morphological marker. A total of 858 GTG-banded mitoses from 61 women with different hematological malignancies were analyzed, 35 of them with normal karyotype and 26 with chromosome aberrations. The folding patterns and the fold percentage remained unchanged in our patients. Using this marker, X-inactivation could easily be verified in leukemia and related disorders on routine preparations.

Entities:  

Mesh：

Year:  1989        PMID： 2737671     DOI： 10.1007/bf00274003

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  8 in total

1.  A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis.

Authors:  M L BARR; E G BERTRAM
Journal:  Nature       Date:  1949-04-30       Impact factor: 49.962

2.  Asynchronous duplication of human chromosomes and the origin of sex chromatin.

Authors:  A MORISHIMA; M M GRUMBACH; J H TAYLOR
Journal:  Proc Natl Acad Sci U S A       Date:  1962-05-15       Impact factor: 11.205

3.  A practical metaphase marker of the inactive X chromosome.

Authors:  D L Van Dyke; W L Flejter; M J Worsham; J R Roberson; J V Higgins; H M Herr; S Knuutila; N Wang; V R Babu; L Weiss
Journal:  Am J Hum Genet       Date:  1986-07       Impact factor: 11.025

4.  Cytogenetic evidence for the absence of an inactivated X chromosome in a human female (XX) breast carcinoma cell line.

Authors:  M Camargo; N Wang
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

5.  Bends in human mitotic metaphase chromosomes, including a bend marking the X-inactivation center.

Authors:  W L Flejter; D L Van Dyke; L Weiss
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

6.  The human inactivated X chromosome folds in early metaphase, prometaphase, and prophase.

Authors:  D L Van Dyke; M Worsham; L Weiss
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

7.  Gene action in the X-chromosome of the mouse (Mus musculus L.).

Authors:  M F LYON
Journal:  Nature       Date:  1961-04-22       Impact factor: 49.962

8.  Separation of the genetic loci for the H-Y antigen and for testis determination on human Y chromosome.

Authors:  E Simpson; P Chandler; E Goulmy; C M Disteche; M A Ferguson-Smith; D C Page
Journal:  Nature       Date:  1987 Apr 30-May 6       Impact factor: 49.962
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.