Guang Yang1, Xiaoyuan Zhang1, Qingyang Meng2, Dan Ma3, Huai Yu1, Xuefeng Ren1, Bo Lv1, Shaosong Zhang4, Shuang Yang5, Bo Yu6. 1. Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. 2. The 3rd Department of Infectious Diseases, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. 3. The 3rd Department of Internal Medicine, Fujin Central Hospital, Fujin, Heilongjiang Province, China. 4. Goodman, 5F KDX Nagoya Salae Building 5-3, 4-Chome, Sakae, Naka-ku, Nagoya, 460-0008, Japan. 5. Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: dryangshuang@126.com. 6. Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: yubodr@163.com.
Abstract
AIM: The purpose of this study was to provide a new assessable method of the optical coherence tomography (OCT) in characterization of thrombi with different concentrations of red blood cell (RBC). METHODS AND RESULTS: A series of thrombus models were constructed by using human blood in vitro. The thrombi were made by using human blood with different concentration of RBC (from 1% to 35%). Then tip of an FD-OCT catheter was put on the top of the thrombus to scan. After OCT being performed, all the acquired images were processed by a newly developed software to analyze the RBC levels related thrombus characteristics including attenuation, backscattering and light penetration depth. The attenuation was correlated with RBC concentration up to 9%. However, no apparent change was observed in thrombus with RBC concentration range from 10% to 35%. The same trend was seen in backscattering and penetration depth. CONCLUSIONS: FD-OCT is able to detect thrombus with different RBC concentrations up to 9%.
AIM: The purpose of this study was to provide a new assessable method of the optical coherence tomography (OCT) in characterization of thrombi with different concentrations of red blood cell (RBC). METHODS AND RESULTS: A series of thrombus models were constructed by using human blood in vitro. The thrombi were made by using human blood with different concentration of RBC (from 1% to 35%). Then tip of an FD-OCT catheter was put on the top of the thrombus to scan. After OCT being performed, all the acquired images were processed by a newly developed software to analyze the RBC levels related thrombus characteristics including attenuation, backscattering and light penetration depth. The attenuation was correlated with RBC concentration up to 9%. However, no apparent change was observed in thrombus with RBC concentration range from 10% to 35%. The same trend was seen in backscattering and penetration depth. CONCLUSIONS: FD-OCT is able to detect thrombus with different RBC concentrations up to 9%.
Authors: Timo P Kaivosoja; Shengnan Liu; Jouke Dijkstra; Heini Huhtala; Tej Sheth; Olli A Kajander Journal: PLoS One Date: 2018-12-17 Impact factor: 3.240