Literature DB >> 2737265

Synthesis of O1.5-(beta-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide, a new highly potent analgesic enkephalin-related glycosyl peptide.

J L Torres1, I Haro, G Valencia, F Reig, J M García-Antón.   

Abstract

A new series of O-glycosyl enkephalins has been prepared, following a convergent strategy, with high chemical yields. The galactosyl analogue, O1.5-(beta-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide proved to be one of the most potent in vivo opioid agonists synthesized up to now.

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Year:  1989        PMID： 2737265     DOI： 10.1007/bf01990511

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.

Authors:  G Gacel; J M Zajac; P Delay-Goyet; V Daugé; B P Roques
Journal:  J Med Chem       Date:  1988-02       Impact factor: 7.446

2.  [D-Met2,Pro5] enkephalin [N1.5-beta-D-glucopyranosyl] amide: a glycosylpeptide with high antinociceptive activity.

Authors:  J L Torres; F Reig; G Valencia; R E Rodríguez; J M García-Antón
Journal:  Int J Pept Protein Res       Date:  1988-05

3.  In vitro profile of some opioid pentapeptide analogues.

Authors:  J S Shaw; M J Turnbull
Journal:  Eur J Pharmacol       Date:  1978-06-01       Impact factor: 4.432

4.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

5.  Biological activity of Leu-enkephalin containing hydrophobic moieties.

Authors:  R E Rodriguez; F Reig; G Valencia; J F Herrero; J Garcia Anton
Journal:  Neuropeptides       Date:  1986 Nov-Dec       Impact factor: 3.286
  5 in total

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