| Literature DB >> 27367968 |
Samantha L Isenberg1, Melissa D Carter2, Shelby R Hayes3, Leigh Ann Graham1, Darryl Johnson3, Thomas P Mathews1, Leslie A Harden4, Gary R Takeoka4, Jerry D Thomas2, James L Pirkle2, Rudolph C Johnson2.
Abstract
Methylenecyclopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in some soapberry fruits. Fatalities have been reported worldwide as a result of HGA ingestion, and exposure to MCPG has been implicated recently in the Asian outbreaks of hypoglycemic encephalopathy. In response to an outbreak linked to soapberry ingestion, the authors developed the first method to simultaneously quantify MCPG and HGA in soapberry fruits from 1 to 10 000 ppm of both toxins in dried fruit aril. Further, this is the first report of HGA in litchi, longan, and mamoncillo arils. This method is presented to specifically address the laboratory needs of public-health investigators in the hypoglycemic encephalitis outbreaks linked to soapberry fruit ingestion.Entities:
Keywords: Acer; Aceraceae; Aesculus; Litchi; Sapindaceae; ackee; cyclopropylamino acids; hypoglycin A; lychee; methylenecyclopropylalanine; methylenecyclopropylglycine; rambutan; soapberry
Mesh：
Substances：
Year: 2016 PMID： 27367968 PMCID： PMC5098216 DOI： 10.1021/acs.jafc.6b02478
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279