Ajay Malik1, R N Mishra2, B Fanthome3, Ramesh Rao4, S R Patrikar5. 1. Associate Professor, Department of Pathology, AFMC, Pune - 40. 2. Ex-Commanding Officer, INHS Kalyani. 3. Commanding Officer, INHS Kalyani. 4. Classified Specialist (Pathology), INHS Asvini. 5. Biostatistician, Department of Community Medicine, AFMC, Pune - 40.
Abstract
BACKGROUND: Angiogenesis is critical for the growth of colorectal carcinoma (CRC). Vascular endothelial growth factor is the most important angiogenic growth factor. METHOD: Fifty cases of CRC operated at INHS Asvini were studied by using immunohistochemical labelling of the tumours by using CD34, p53, and vascular endothelial growth factor (VEGF). RESULTS: Out of the 50 cases, 31 (62%) were positive for p53; of which 80.7% showed high expression. Significant staining (> 20% tumour cells showing positivity) was seen in 33 patients (66%), while 34% were negative. Of the 33 positive cases, 57.58% showed high-grade VEGF positivity. CONCLUSION: Vascular endothelial growth factor correlated significantly with the stage and grade of disease. Intra tumours microvessel density as calculated from CD34 expression increased with the stage and grade of the CRC.
BACKGROUND: Angiogenesis is critical for the growth of colorectal carcinoma (CRC). Vascular endothelial growth factor is the most important angiogenic growth factor. METHOD: Fifty cases of CRC operated at INHS Asvini were studied by using immunohistochemical labelling of the tumours by using CD34, p53, and vascular endothelial growth factor (VEGF). RESULTS: Out of the 50 cases, 31 (62%) were positive for p53; of which 80.7% showed high expression. Significant staining (> 20% tumour cells showing positivity) was seen in 33 patients (66%), while 34% were negative. Of the 33 positive cases, 57.58% showed high-grade VEGF positivity. CONCLUSION:Vascular endothelial growth factor correlated significantly with the stage and grade of disease. Intra tumours microvessel density as calculated from CD34 expression increased with the stage and grade of the CRC.
Authors: Gennaro Galizia; Francesca Ferraraccio; Eva Lieto; Michele Orditura; Paolo Castellano; Vincenzo Imperatore; Ciro Romano; Mario Vollaro; Bruno Agostini; Carlo Pignatelli; Ferdinando De Vita Journal: Dis Colon Rectum Date: 2004-11 Impact factor: 4.585