AIM: To clarify the association of vascular endothelial growth factor (VEGF) and microvascular density (MVD) expression with the angiogenesis and prognosis of colorectal cancer. METHODS: A total of 97 cases of colorectal carcinomas were examined by immunohistochemical staining (SP method), using anti-VEGF and anti-factor CD34(+) monoclonal antibodies. RESULTS: VEGF positive staining was obtained in 68 out of 97 cases (70.1 %), and observed mainly in the cytoplasm of tumor cells, and also frequently in stromal cells. VEGF expression was more intense in poorly differentiated adenocarcinoma in comparison with others, but there was no significant correlation between VEGF expression and age, sex and stage. A significant correlation was found between the MVD and grades, and there was no significant relationship between the MVD and age, sex, and stage. The MVD in the VEGF positive group (68 cases) was higher than that in the negative group. Upon multivariate analysis, the significant variables were stage, tumor grade and MVD; VEGF expression was not an independent prognostic factor. CONCLUSION: The expression of VEGF has a significant correlation with MVD; MVD expression has prognostic value but VEGF has not in colon cancer.
AIM: To clarify the association of vascular endothelial growth factor (VEGF) and microvascular density (MVD) expression with the angiogenesis and prognosis of colorectal cancer. METHODS: A total of 97 cases of colorectal carcinomas were examined by immunohistochemical staining (SP method), using anti-VEGF and anti-factor CD34(+) monoclonal antibodies. RESULTS:VEGF positive staining was obtained in 68 out of 97 cases (70.1 %), and observed mainly in the cytoplasm of tumor cells, and also frequently in stromal cells. VEGF expression was more intense in poorly differentiated adenocarcinoma in comparison with others, but there was no significant correlation between VEGF expression and age, sex and stage. A significant correlation was found between the MVD and grades, and there was no significant relationship between the MVD and age, sex, and stage. The MVD in the VEGF positive group (68 cases) was higher than that in the negative group. Upon multivariate analysis, the significant variables were stage, tumor grade and MVD; VEGF expression was not an independent prognostic factor. CONCLUSION: The expression of VEGF has a significant correlation with MVD; MVD expression has prognostic value but VEGF has not in colon cancer.
Authors: K Inoue; J W Slaton; T Karashima; C Yoshikawa; T Shuin; P Sweeney; R Millikan; C P Dinney Journal: Clin Cancer Res Date: 2000-12 Impact factor: 12.531
Authors: O N El-Assal; A Yamanoi; Y Soda; M Yamaguchi; M Igarashi; A Yamamoto; T Nabika; N Nagasue Journal: Hepatology Date: 1998-06 Impact factor: 17.425
Authors: S Uchida; Y Shimada; G Watanabe; H Tanaka; I Shibagaki; T Miyahara; S Ishigami; M Imamura Journal: Br J Cancer Date: 1998-05 Impact factor: 7.640
Authors: Luciana Regina Moreira; André Almeida Schenka; Paulo Latuf-Filho; André Lisboa Penná; Carmen S P Lima; Fernando Augusto Soares; Miriam Aparecida Silva Trevisan; José Vassallo Journal: Tumour Biol Date: 2011-01-08
Authors: Rafael Uribarrena A; Javier Ortego; Javier Fuentes; Nuria Raventós; Pilar Parra; Rafael Uribarrena E Journal: Gastroenterol Res Pract Date: 2009-11-04 Impact factor: 2.260
Authors: A M Jubb; H Turley; H C Moeller; G Steers; C Han; J-L Li; R Leek; E Y Tan; B Singh; N J Mortensen; I Noguera-Troise; F Pezzella; K C Gatter; G Thurston; S B Fox; A L Harris Journal: Br J Cancer Date: 2009-10-20 Impact factor: 7.640