Seda Ates1, Osman Sevket1, Pinar Ozcan1, Fulya Ozkal1, Mehmet Onur Kaya2, Banu Dane1. 1. Bezmialem Vakif University, Faculty of Medicine, Department of Obstetrics and Gynecology, Istanbul, Turkey. 2. Bezmialem Vakif University, Faculty of Medicine, Department of Biostatistics and Medical Informatics, Istanbul, Turkey.
Abstract
OBJECTIVE: To assess serum levels of 25-hydroxyvitamin D [25(OH)D] in the first trimester and to determine the factors affecting deficiency levels and its association with pregnancy outcomes. METHODS: Serum 25(OH)D concentrations were measured at 11-14 weeks' gestation in 229 singleton pregnancies using liquid chromatography-tandem mass spectrometry. RESULTS: The median serum 25(OH)D concentration was 10.8 ng/mL and 45.9% of women had severe vitamin D deficiency with concentrations of <10 ng/mL. Logistic regression analysis revealed that covered dressing style, lack of multivitamin intake, season of blood sampling (November-April) were factors associated with 25(OH)D deficiency. There was a negative correlation between 25(OH)D levels and gestational age at sampling. Low 25(OH)D levels were not associated with adverse pregnancy outcomes. Higher rate of cesarean section (CS) was noted in women with 25(OH)D ≥10 ng/mL compared to those with 25(OH)D < 10mg/ml (p= 0.01). CONCLUSION: A high prevalence of vitamin D deficiency was observed in early pregnancy which was related to dress code, use of multi-vitamins and season at sampling. Low 25(OH)D levels were not related with adverse pregnancy outcomes. Women with severe vitamin D deficiency were more likely to deliver vaginally.
OBJECTIVE: To assess serum levels of 25-hydroxyvitamin D [25(OH)D] in the first trimester and to determine the factors affecting deficiency levels and its association with pregnancy outcomes. METHODS: Serum 25(OH)D concentrations were measured at 11-14 weeks' gestation in 229 singleton pregnancies using liquid chromatography-tandem mass spectrometry. RESULTS: The median serum 25(OH)D concentration was 10.8 ng/mL and 45.9% of women had severe vitamin D deficiency with concentrations of <10 ng/mL. Logistic regression analysis revealed that covered dressing style, lack of multivitamin intake, season of blood sampling (November-April) were factors associated with 25(OH)D deficiency. There was a negative correlation between 25(OH)D levels and gestational age at sampling. Low 25(OH)D levels were not associated with adverse pregnancy outcomes. Higher rate of cesarean section (CS) was noted in women with 25(OH)D ≥10 ng/mL compared to those with 25(OH)D < 10mg/ml (p= 0.01). CONCLUSION: A high prevalence of vitamin D deficiency was observed in early pregnancy which was related to dress code, use of multi-vitamins and season at sampling. Low 25(OH)D levels were not related with adverse pregnancy outcomes. Women with severe vitamin D deficiency were more likely to deliver vaginally.
Entities:
Keywords:
25-hydroxyvitamin D; pregnancy outcome; vitamin D deficiency
Authors: Anne Merewood; Supriya D Mehta; Tai C Chen; Howard Bauchner; Michael F Holick Journal: J Clin Endocrinol Metab Date: 2008-12-23 Impact factor: 5.958
Authors: Sara Al-Musharaf; Mona A Fouda; Iqbal Z Turkestani; Abdulrahman Al-Ajlan; Shaun Sabico; Abdullah M Alnaami; Kaiser Wani; Syed Danish Hussain; Buthaynah Alraqebah; Amal Al-Serehi; Naemah M Alshingetti; Nasser Al-Daghri; Philip G McTernan; Sunil J Wimalawansa; Ponnusamy Saravanan Journal: Nutrients Date: 2018-04-15 Impact factor: 5.717
Authors: Paige van der Pligt; Jane Willcox; Ewa A Szymlek-Gay; Emily Murray; Anthony Worsley; Robin M Daly Journal: Nutrients Date: 2018-05-18 Impact factor: 5.717
Authors: Jussara Mayrink; Debora F Leite; Guilherme M Nobrega; Maria Laura Costa; Jose Guilherme Cecatti Journal: BMJ Open Date: 2022-04-25 Impact factor: 3.006
Authors: María Morales-Suárez-Varela; Nazlı Uçar; José Miguel Soriano; Agustín Llopis-Morales; Beth S Sanford; William B Grant Journal: Nutrients Date: 2022-10-04 Impact factor: 6.706
Authors: Heng Yaw Yong; Zalilah Mohd Shariff; Lalitha Palaniveloo; Su Peng Loh; Barakatun Nisak Mohd Yusof; Zulida Rejali; Jacques Bindels; Yvonne Yee Siang Tee; Eline M van der Beek Journal: Nutr Res Pract Date: 2021-08-12 Impact factor: 1.926