Literature DB >> 27354294

Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.

Irina V Tiper1, James E East1, Priyanka B Subrahmanyam1, Tonya J Webb2.   

Abstract

Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained from ceramide. S1P is known to be an important signaling molecule and plays multiple roles in the context of immunity. This lysophospholipid binds and activates G-protein-coupled receptors (GPCRs) known as S1P receptors 1-5 (S1P1-5). Once activated, these GPCRs mediate signaling that can lead to alterations in cell proliferation, survival or migration, and can also have other effects such as promoting angiogenesis. In this review, we will present evidence demonstrating a role for S1P in lymphocyte migration, inflammation and infection, as well as in cancer. The therapeutic potential of targeting S1P receptors, kinases and lyase will also be discussed. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  FTY720; S1P; lymphocyte trafficking; sphingosine

Mesh：

Substances：

Year:  2016        PMID： 27354294      PMCID： PMC5985508          DOI： 10.1093/femspd/ftw063

Source DB:  PubMed          Journal:  Pathog Dis        ISSN： 2049-632X            Impact factor:   3.166


  85 in total

1.  Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

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Journal:  Science       Date:  2002-03-28       Impact factor: 47.728

Review 2.  Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

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Review 3.  Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.

Authors:  Gregory T Kunkel; Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Journal:  Nat Rev Drug Discov       Date:  2013-08-19       Impact factor: 84.694

4.  FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration.

Authors:  Su Jin Hwang; Ji Hyung Kim; Hye Young Kim; Sanghee Kim; Doo Hyun Chung
Journal:  Lab Invest       Date:  2009-10-12       Impact factor: 5.662

5.  Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?

Authors:  Sanjay K Garg; Marilina B Santucci; Miriam Panitti; Leo Pucillo; Marialuisa Bocchino; Fumikazu Okajima; Prakash S Bisen; Cesare Saltini; Maurizio Fraziano
Journal:  Clin Immunol       Date:  2006-10-16       Impact factor: 3.969

6.  FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.

Authors:  K Chiba; Y Yanagawa; Y Masubuchi; H Kataoka; T Kawaguchi; M Ohtsuki; Y Hoshino
Journal:  J Immunol       Date:  1998-05-15       Impact factor: 5.422

7.  FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells.

Authors:  Craig T Wallington-Beddoe; John Hewson; Kenneth F Bradstock; Linda J Bendall
Journal:  Autophagy       Date:  2011-07-01       Impact factor: 16.016

8.  Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function.

Authors:  A K Gandhi; J Kang; L Capone; A Parton; L Wu; L H Zhang; D Mendy; A Lopez-Girona; T Tran; L Sapinoso; W Fang; S Xu; G Hampton; J B Bartlett; P Schafer
Journal:  Curr Cancer Drug Targets       Date:  2010-03       Impact factor: 3.428

9.  Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis.

Authors:  Qing-Fang Li; Chu-Tse Wu; Hai-Feng Duan; Hui-Yan Sun; Hua Wang; Zhuo-Zhuang Lu; Qun-Wei Zhang; Hong-Jun Liu; Li-Sheng Wang
Journal:  Br J Haematol       Date:  2007-09       Impact factor: 6.998

Review 10.  Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.

Authors:  Yun Zhang; Yan Wang; Zhi Wan; Shiping Liu; Yu Cao; Zhi Zeng
Journal:  PLoS One       Date:  2014-02-27       Impact factor: 3.240
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  18 in total

1.  Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation.

Authors:  Veit Rothhammer; Jessica E Kenison; Emily Tjon; Maisa C Takenaka; Kalil Alves de Lima; Davis M Borucki; Chun-Cheih Chao; Annabel Wilz; Manon Blain; Luke Healy; Jack Antel; Francisco J Quintana
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-06       Impact factor: 11.205

2.  Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts.

Authors:  SiddabasaveGowda B Gowda; Divyavani Gowda; Vasundhara Kain; Hitoshi Chiba; Shu-Ping Hui; Charles E Chalfant; Vibhu Parcha; Pankaj Arora; Ganesh V Halade
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-08-20       Impact factor: 4.733

3.  Sphingosine 1-Phosphate Receptors in Cerebral Ischemia.

Authors:  Bhakta Prasad Gaire; Ji Woong Choi
Journal:  Neuromolecular Med       Date:  2020-09-10       Impact factor: 3.843

4.  Where Have All the T Cells Gone?

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5.  Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.

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Review 6.  Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer.

Authors:  Cristina Aguirre-Portolés; Lara P Fernández; Ana Ramírez de Molina
Journal:  Nutrients       Date:  2017-09-28       Impact factor: 5.717

7.  Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection.

Authors:  Björn Ambrosius; Kalliopi Pitarokoili; Lisa Schrewe; Xiomara Pedreiturria; Jeremias Motte; Ralf Gold
Journal:  J Neuroinflammation       Date:  2017-04-26       Impact factor: 8.322

Review 8.  The role of sphingosine-1-phosphate in inflammation and cancer progression.

Authors:  Masayuki Nagahashi; Manabu Abe; Kenji Sakimura; Kazuaki Takabe; Toshifumi Wakai
Journal:  Cancer Sci       Date:  2018-10-15       Impact factor: 6.716

Review 9.  The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer.

Authors:  Nitai C Hait; Aparna Maiti
Journal:  Mediators Inflamm       Date:  2017-11-15       Impact factor: 4.711

10.  Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase.

Authors:  Manal Elzoheiry; Akram A Da'dara; Rita Bhardwaj; Qiang Wang; Manar S Azab; El-Saeed I El-Kholy; Samar N El-Beshbishi; Patrick J Skelly
Journal:  Front Immunol       Date:  2018-07-30       Impact factor: 7.561
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