| Literature DB >> 27353278 |
Motoh Iwasa1, Ryosuke Sugimoto2, Rumi Mifuji-Moroka2, Nagisa Hara3, Kyoko Yoshikawa2, Hideaki Tanaka2, Akiko Eguchi2, Norihiko Yamamoto2, Kazushi Sugimoto2, Yoshinao Kobayashi2, Hiroshi Hasegawa2, Yoshiyuki Takei2.
Abstract
The aim of this study was to clarify the relationships among psychometric testing results, blood ammonia (NH3) levels, electrolyte abnormalities, and degree of inflammation, and their associations with the development of overt hepatic encephalopathy (HE) in liver cirrhosis (LC) patients. The relationships between covert HE and blood NH3, sodium (Na), and C-reactive protein (CRP) were examined in 40 LC patients. The effects of elevated NH3, hyponatremia, and elevated CRP on the development of overt HE were also investigated. The covert HE group had significantly lower serum Na levels and significantly higher serum CRP levels. During the median observation period of 11 months, 10 patients developed overt HE, and the results of multivariate analysis showed that covert HE and elevated blood NH3 were factors contributing to the development of overt HE. Electrolyte abnormalities and mild inflammation are involved in the pathogenesis of HE. Abnormal psychometric testing results and hyperammonemia are linked to subsequent development of overt HE.Entities:
Keywords: Ammonia; Hepatic encephalopathy; Hyponatremia; Inflammation; Liver cirrhosis
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Year: 2016 PMID： 27353278 DOI： 10.1007/s11011-016-9862-6
Source DB: PubMed Journal: Metab Brain Dis ISSN： 0885-7490 Impact factor: 3.584