| Literature DB >> 27352184 |
Xingre Lu1, Fengyu Chen2, Xiaowen Liu2, Diao Yuan2, Yunju Zi2, Xiang He2, Running He2.
Abstract
Gastric cancer has high morbidity and mortality. Identification of patients with high gastric cancer risk at early stage will improve patient prognosis. In this study, we examined two single nucleotide polymorphism (SNP) sites of COX-2 gene in gastric cancer patients and explored the effect of the SNPs on the morbidity of gastric cancer. We found that the SNPs COX-2-1195G/A and COX-2-8473T/C are correlated with the occurrence of gastric cancer, and the patients with variants A and C of the SNPs are liable to have gastric cancer. Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients.Entities:
Keywords: COX-2 gene; Gastric cancer; Genetic susceptibility; Single nucleotide polymorphism
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Year: 2015 PMID： 27352184 DOI： 10.1007/s12013-014-0465-8
Source DB: PubMed Journal: Cell Biochem Biophys ISSN： 1085-9195 Impact factor: 2.194