Tatsuya Hayashi1,2,3,4, Satoshi Saitoh2,5,6, Junji Takahashi1,2, Yoshinori Tsuji1,2, Kenji Ikeda2,5, Masahiro Kobayashi2,5, Yusuke Kawamura2,5, Takeshi Fujii2,7, Masafumi Inoue8, Tosiaki Miyati3, Hiromitsu Kumada2,5. 1. Department of Radiological Technology, Toranomon Hospital, Tokyo, Japan. 2. Okinaka Memorial Institute for Medical Research, Tokyo, Japan. 3. Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. 4. Department of Medical Radiology, Faculty of Medical Technology, Teikyo University, Tokyo, Japan. 5. Department of Hepatology, Toranomon Hospital, Tokyo, Japan. 6. Department of Radiology, Toranomon Hospital, Tokyo, Japan. 7. Department of Pathology, Toranomon Hospital, Tokyo, Japan. 8. Department of Ophthalmology, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Tokyo, Japan.
Abstract
AIM: The two-point Dixon method for magnetic resonance imaging (MRI) is commonly used to non-invasively measure fat deposition in the liver. The aim of the present study was to assess the usefulness of MRI-fat fraction (MRI-FF) using the two-point Dixon method based on the non-alcoholic fatty liver disease activity score. METHODS: This retrospective study included 106 patients who underwent liver MRI and MR spectroscopy, and 201 patients who underwent liver MRI and histological assessment. The relationship between MRI-FF and MR spectroscopy-fat fraction was used to estimate the corrected MRI-FF for hepatic multi-peaks of fat. Then, a color FF map was generated with the corrected MRI-FF based on the non-alcoholic fatty liver disease activity score. We defined FF variability as the standard deviation of FF in regions of interest. Uniformity of hepatic fat was visually graded on a three-point scale using both gray-scale and color FF maps. Confounding effects of histology (iron, inflammation and fibrosis) on corrected MRI-FF were assessed by multiple linear regression. RESULTS: The linear correlations between MRI-FF and MR spectroscopy-fat fraction, and between corrected MRI-FF and histological steatosis were strong (R2 = 0.90 and R2 = 0.88, respectively). Liver fat variability significantly increased with visual fat uniformity grade using both of the maps (ρ = 0.67-0.69, both P < 0.001). Hepatic iron, inflammation and fibrosis had no significant confounding effects on the corrected MRI-FF (all P > 0.05). CONCLUSIONS: The two-point Dixon method and the gray-scale or color FF maps based on the non-alcoholic fatty liver disease activity score were useful for fat quantification in the liver of patients without severe iron deposition.
AIM: The two-point Dixon method for magnetic resonance imaging (MRI) is commonly used to non-invasively measure fat deposition in the liver. The aim of the present study was to assess the usefulness of MRI-fat fraction (MRI-FF) using the two-point Dixon method based on the non-alcoholic fatty liver disease activity score. METHODS: This retrospective study included 106 patients who underwent liver MRI and MR spectroscopy, and 201 patients who underwent liver MRI and histological assessment. The relationship between MRI-FF and MR spectroscopy-fat fraction was used to estimate the corrected MRI-FF for hepatic multi-peaks of fat. Then, a color FF map was generated with the corrected MRI-FF based on the non-alcoholic fatty liver disease activity score. We defined FF variability as the standard deviation of FF in regions of interest. Uniformity of hepatic fat was visually graded on a three-point scale using both gray-scale and color FF maps. Confounding effects of histology (iron, inflammation and fibrosis) on corrected MRI-FF were assessed by multiple linear regression. RESULTS: The linear correlations between MRI-FF and MR spectroscopy-fat fraction, and between corrected MRI-FF and histological steatosis were strong (R2 = 0.90 and R2 = 0.88, respectively). Liver fat variability significantly increased with visual fat uniformity grade using both of the maps (ρ = 0.67-0.69, both P < 0.001). Hepatic iron, inflammation and fibrosis had no significant confounding effects on the corrected MRI-FF (all P > 0.05). CONCLUSIONS: The two-point Dixon method and the gray-scale or color FF maps based on the non-alcoholic fatty liver disease activity score were useful for fat quantification in the liver of patients without severe iron deposition.
Authors: Ziying Yin; Matthew C Murphy; Jiahui Li; Kevin J Glaser; Amy S Mauer; Taofic Mounajjed; Terry M Therneau; Heshan Liu; Harmeet Malhi; Armando Manduca; Richard L Ehman; Meng Yin Journal: Eur Radiol Date: 2019-03-18 Impact factor: 5.315
Authors: Jingbiao Chen; Rosa Martin-Mateos; Jiahui Li; Ziying Yin; Jie Chen; Xin Lu; Kevin J Glaser; Taofic Mounajjed; Hiroaki Yashiro; Jenifer Siegelman; Christopher T Winkelmann; Jin Wang; Richard L Ehman; Vijay H Shah; Meng Yin Journal: Alcohol Clin Exp Res Date: 2021-09-05 Impact factor: 3.928