| Literature DB >> 27350449 |
Panagiotis Mistriotis1, Vivek K Bajpai1, Xiaoyan Wang1, Na Rong1, Aref Shahini1, Mohammadnabi Asmani2, Mao-Shih Liang1, Jianmin Wang3, Pedro Lei1, Song Liu3, Ruogang Zhao2, Stelios T Andreadis1,2.
Abstract
Cellular senescence as a result of organismal aging or progeroid diseases leads to stem cell pool exhaustion hindering tissue regeneration and contributing to the progression of age related disorders. Here we discovered that ectopic expression of the pluripotent factor NANOG in senescent or progeroid myogenic progenitors reversed cellular aging and restored completely the ability to generate contractile force. To elicit its effects, NANOG enabled reactivation of the ROCK and Transforming Growth Factor (TGF)-β pathways-both of which were impaired in senescent cells-leading to ACTIN polymerization, MRTF-A translocation into the nucleus and serum response factor (SRF)-dependent myogenic gene expression. Collectively our data reveal that cellular senescence can be reversed and provide a novel strategy to regain the lost function of aged stem cells without reprogramming to the pluripotent state. Stem Cells 2017;35:207-221.Entities:
Keywords: ACTIN polymerization; Aging; Contraction; NANOG; Progeria; SRF; Senescence; Smooth muscle differentiation; Stem cells
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Year: 2016 PMID： 27350449 DOI： 10.1002/stem.2452
Source DB: PubMed Journal: Stem Cells ISSN： 1066-5099 Impact factor: 6.277