| Literature DB >> 27346355 |
Naidu M Vegi1, Josef Klappacher1, Franz Oswald2, Medhanie A Mulaw1, Amit Mandoli3, Verena N Thiel2, Shiva Bamezai1, Kristin Feder1, Joost H A Martens3, Vijay P S Rawat1, Tamoghna Mandal1, Leticia Quintanilla-Martinez4, Karsten Spiekermann5, Wolfgang Hiddemann5, Konstanze Döhner6, Hartmut Döhner6, Hendrik G Stunnenberg3, Michaela Feuring-Buske6, Christian Buske7.
Abstract
Homeobox genes are known to be key factors in leukemogenesis. Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a role for MEIS2 is less clear. Here, we demonstrate that MEIS2 is expressed at high levels in patients with AML1-ETO-positive acute myeloid leukemia and that growth of AML1-ETO-positive leukemia depends on MEIS2 expression. In mice, MEIS2 collaborates with AML1-ETO to induce acute myeloid leukemia. MEIS2 binds strongly to the Runt domain of AML1-ETO, indicating a direct interaction between these transcription factors. High expression of MEIS2 impairs repressive DNA binding of AML1-ETO, inducing increased expression of genes such as the druggable proto-oncogene YES1. Collectively, these data describe a pivotal role for MEIS2 in AML1-ETO-induced leukemia.Entities:
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Year: 2016 PMID： 27346355 DOI： 10.1016/j.celrep.2016.05.094
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423