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Literature DB >> 27342132

Kynurenines, Gender and Neuroinflammation; Showcase Schizophrenia.

Abstract

Schizophrenia has a clear sexual dimorphism in age of onset and progression. The underlying mechanisms of this dimorphism are not known, but may be found in the interactions of sex hormones with the tryptophan catabolising kynurenine pathway. Schizophrenia is associated with general inflammation and disruption of glutamatergic and dopaminergic signalling. Metabolites of the kynurenine pathway have been shown to be immunomodulatory and have effects on glutamatergic and dopaminergic signalling. This review discusses the currently available literature on sex hormones and their effect on the kynurenine pathway in the context of the glutamatergic, dopaminergic and immunological features of schizophrenia.

Entities: Chemical Disease

Keywords: Gender; Inflammation; Kynurenine pathway; Schizophrenia; Tryptophan

Mesh：

Substances：
Kynurenine

Year: 2016 PMID： 27342132 DOI： 10.1007/s12640-016-9641-5

Source DB: PubMed Journal: Neurotox Res ISSN： 1029-8428 Impact factor: 3.911

65 in total

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Journal: Schizophr Res Date: 1991-09 Impact factor: 4.939

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Authors: S G Fillman; N Cloonan; V S Catts; L C Miller; J Wong; T McCrossin; M Cairns; C S Weickert
Journal: Mol Psychiatry Date: 2012-08-07 Impact factor: 15.992

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Journal: J Clin Pathol Date: 1972-01 Impact factor: 3.411

5. Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection.

Authors: G J Guillemin; S J Kerr; G A Smythe; D G Smith; V Kapoor; P J Armati; J Croitoru; B J Brew
Journal: J Neurochem Date: 2001-08 Impact factor: 5.372

6. Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients.

Authors: A M Myint; M J Schwarz; R Verkerk; H H Mueller; J Zach; S Scharpé; H W M Steinbusch; B E Leonard; Y K Kim
Journal: Brain Behav Immun Date: 2011-05-17 Impact factor: 7.217

7. The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.

Authors: C Hilmas; E F Pereira; M Alkondon; A Rassoulpour; R Schwarcz; E X Albuquerque
Journal: J Neurosci Date: 2001-10-01 Impact factor: 6.167

8. Sex Differences Distinguish Intracortical Glutamate Receptor-Mediated Regulation of Extracellular Dopamine Levels in the Prefrontal Cortex of Adult Rats.

Authors: M N Locklear; A B Cohen; A Jone; M F Kritzer
Journal: Cereb Cortex Date: 2014-09-26 Impact factor: 5.357

9. Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta.

Authors: Ann E Baker; Vielska M Brautigam; Jyoti J Watters
Journal: Endocrinology Date: 2004-07-15 Impact factor: 4.736

10. Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege.

Authors: Madison C Cuffy; Amanda M Silverio; Lingfeng Qin; Yinong Wang; Raymond Eid; Gerald Brandacher; Fadi G Lakkis; Dietmar Fuchs; Jordan S Pober; George Tellides
Journal: J Immunol Date: 2007-10-15 Impact factor: 5.422

10 in total

1. Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects.

Authors: K V Sathyasaikumar; M Tararina; H-Q Wu; S A Neale; F Weisz; T E Salt; R Schwarcz
Journal: Neuroscience Date: 2017-10-12 Impact factor: 3.590

Review 2. Galantamine-Memantine Combination and Kynurenine Pathway Enzyme Inhibitors in the Treatment of Neuropsychiatric Disorders.

Authors: Michael Y Bai; David B Lovejoy; Gilles J Guillemin; Rouba Kozak; Trevor W Stone; Maju Mathew Koola
Journal: Complex Psychiatry Date: 2021-02-08

3. Progesterone Alters Kynurenine Pathway Activation in IFN-γ-Activated Macrophages - Relevance for Neuroinflammatory Diseases.

Authors: J de Bie; C K Lim; G J Guillemin
Journal: Int J Tryptophan Res Date: 2016-12-07

Review 4. Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation.

Authors: George Anderson; Michael Maes
Journal: Int J Tryptophan Res Date: 2017-02-16

5. Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.

Authors: Pratishtha Chatterjee; Kathryn Goozee; Chai K Lim; Ian James; Kaikai Shen; Kelly R Jacobs; Hamid R Sohrabi; Tejal Shah; Prita R Asih; Preeti Dave; Candice ManYan; Kevin Taddei; David B Lovejoy; Roger Chung; Gilles J Guillemin; Ralph N Martins
Journal: Sci Rep Date: 2018-05-22 Impact factor: 4.379