Poonam K Pannu1, Yun Zhao2, Mario J Soares1, Leonard S Piers3, Zahid Ansari3. 1. 1Health Promotion and Disease Prevention,School of Public Health,Curtin Health Innovation Research Institute (CHIRI), Faculty of Health Sciences,Curtin University,GPO Box U1987,Perth,WA 6845,Australia. 2. 2Occupation and the Environment,School of Public Health, Faculty of Health Sciences,Curtin University,Perth,WA,Australia. 3. 3Health Intelligence Unit,System Intelligence and Analytics Branch,Health Strategy,Productivity and Analytics Division,Department of Health and Human Services,Melbourne,VIC,Australia.
Abstract
OBJECTIVE: To examine the associations between serum 25-hydroxyvitamin D (25(OH)D), dietary Ca intake and presence of the metabolic syndrome (MetS). DESIGN: A stratified cluster sample of a population aged 18-75 years from the Victorian Health Monitor survey. SETTING: Non-institutionalized adults living in private dwellings in Victoria, Australia. SUBJECTS: Adults (n 3404) with complete data and without type 1 or type 2 diabetes. RESULTS: Adjusted for sociodemographic factors, physical characteristics and dietary covariates including Ca intake, every 10 nmol/l increase in serum 25(OH)D was significantly associated with decreased odds of MetS (adjusted odds ratio (AOR)=0·85, 95 % CI 0·80, 0·89; P<0·001). Relative to the low 25(OH)D tertile (median 33 nmol/l), there was a progressive decrease in odds of MetS that reached significance with the high 25(OH)D tertile (median 77 nmol/l; AOR=0·35, 95 % CI 0·26, 0·48; P<0·001). Every 500 mg/d increase in Ca intake adjusted for 25(OH)D did not reduce odds of MetS (AOR=0·81, 95 % CI 0·66, 1·06; P=0·141) but approached significance if unadjusted for 25(OH)D in the final model (AOR=0·81, 95 % CI 0·64, 1·02; P=0·073). No significant effect was obtained for tertiles of Ca intake. However, Ca and vitamin D tertile combinations suggested a beneficial effect of high Ca (median 1233 mg/d) only at low and medium 25(OH)D. The high 25(OH)D tertile was associated with significantly decreased odds of MetS regardless of Ca intake. CONCLUSIONS: A high vitamin D status significantly reduced the odds of MetS. A high Ca intake may have a similar favourable outcome but only at lower circulating concentrations of 25(OH)D.
OBJECTIVE: To examine the associations between serum 25-hydroxyvitamin D (25(OH)D), dietary Ca intake and presence of the metabolic syndrome (MetS). DESIGN: A stratified cluster sample of a population aged 18-75 years from the Victorian Health Monitor survey. SETTING: Non-institutionalized adults living in private dwellings in Victoria, Australia. SUBJECTS: Adults (n 3404) with complete data and without type 1 or type 2 diabetes. RESULTS: Adjusted for sociodemographic factors, physical characteristics and dietary covariates including Ca intake, every 10 nmol/l increase in serum 25(OH)D was significantly associated with decreased odds of MetS (adjusted odds ratio (AOR)=0·85, 95 % CI 0·80, 0·89; P<0·001). Relative to the low 25(OH)D tertile (median 33 nmol/l), there was a progressive decrease in odds of MetS that reached significance with the high 25(OH)D tertile (median 77 nmol/l; AOR=0·35, 95 % CI 0·26, 0·48; P<0·001). Every 500 mg/d increase in Ca intake adjusted for 25(OH)D did not reduce odds of MetS (AOR=0·81, 95 % CI 0·66, 1·06; P=0·141) but approached significance if unadjusted for 25(OH)D in the final model (AOR=0·81, 95 % CI 0·64, 1·02; P=0·073). No significant effect was obtained for tertiles of Ca intake. However, Ca and vitamin D tertile combinations suggested a beneficial effect of high Ca (median 1233 mg/d) only at low and medium 25(OH)D. The high 25(OH)D tertile was associated with significantly decreased odds of MetS regardless of Ca intake. CONCLUSIONS: A high vitamin D status significantly reduced the odds of MetS. A high Ca intake may have a similar favourable outcome but only at lower circulating concentrations of 25(OH)D.
Entities:
Keywords:
25-Hydroxyvitamin D; Calcium; Metabolic syndrome; Vitamin D
Authors: Linda Ahenkorah Fondjo; Samuel Asamoah Sakyi; William K B A Owiredu; Edwin Ferguson Laing; Eddie-Williams Owiredu; Ebenezer Kwesi Awusi; Richard K D Ephraim; Osei Sarfo Kantanka Journal: Biomed Res Int Date: 2018-04-02 Impact factor: 3.411