Poonam K Pannu1, Mario J Soares1, Leonard S Piers2, Yun Zhao3, Zahid Ansari2. 1. Food, Nutrition and Health, School of Public Health, Curtin Health Innovation Research Institute, Curtin University. 2. Department of Health, Health Intelligence Unit, System Intelligence and Analytics Branch, Health Strategy, Productivity and Analytics Division, Melbourne, Victoria, Australia. 3. Occupation and the Environment, School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia.
Abstract
This study examined the associations between 25-hydroxyvitamin D (25-OHD), dietary calcium (Ca) intake, and individual components of the metabolic syndrome (MetS). METHODS: We analyzed a population-based sample of 18-75-year-old adults (n=3387) from the Victorian Health Monitor survey. RESULTS: After adjustment for sociodemographic, physical, and dietary factors, as well as other MetS components, every 10 nmol/l increment in 25-OHD was associated with reduced adjusted odds ratio (AOR) of elevated triglycerides (TG) [AOR: 0.79, 95% confidence interval (CI): 0.74-0.84, P<0.001], and higher fasting plasma glucose (AOR: 0.91, 95% CI: 0.86-0.96, P=0.002). After adjustment for confounders, every 500 mg/day increment in dietary Ca intake significantly reduced the odds of elevated diastolic blood pressure (AOR: 0.80, 95% CI: 0.66-0.99, P=0.038). When nine combinations of 25-OHD and Ca tertiles were examined, certain combinations were associated with reduced AOR for elevated TG (P<0.001), when referenced against the combination of low 25-OHD (median: 33 nmol/l) and low Ca (median: 579 mg/day). At low 25-OHD, increasing Ca intake decreased the AOR for low high-density lipoprotein cholesterol in a dose-dependent manner, but at high 25-OHD; such effects of Ca were blunted. CONCLUSION: Higher vitamin D status and Ca intake or their combination were associated with reduced odds for a number of individual MetS components.
This study examined the associations between 25-hydroxyvitamin D (25-OHD), dietary calcium (Ca) intake, and individual components of the metabolic syndrome (MetS). METHODS: We analyzed a population-based sample of 18-75-year-old adults (n=3387) from the Victorian Health Monitor survey. RESULTS: After adjustment for sociodemographic, physical, and dietary factors, as well as other MetS components, every 10 nmol/l increment in 25-OHD was associated with reduced adjusted odds ratio (AOR) of elevated triglycerides (TG) [AOR: 0.79, 95% confidence interval (CI): 0.74-0.84, P<0.001], and higher fasting plasma glucose (AOR: 0.91, 95% CI: 0.86-0.96, P=0.002). After adjustment for confounders, every 500 mg/day increment in dietary Ca intake significantly reduced the odds of elevated diastolic blood pressure (AOR: 0.80, 95% CI: 0.66-0.99, P=0.038). When nine combinations of 25-OHD and Ca tertiles were examined, certain combinations were associated with reduced AOR for elevated TG (P<0.001), when referenced against the combination of low 25-OHD (median: 33 nmol/l) and low Ca (median: 579 mg/day). At low 25-OHD, increasing Ca intake decreased the AOR for low high-density lipoprotein cholesterol in a dose-dependent manner, but at high 25-OHD; such effects of Ca were blunted. CONCLUSION: Higher vitamin D status and Ca intake or their combination were associated with reduced odds for a number of individual MetS components.
Authors: Lucinda J Black; Denise Anderson; Michael W Clarke; Anne-Louise Ponsonby; Robyn M Lucas Journal: PLoS One Date: 2015-08-12 Impact factor: 3.240