Literature DB >> 27338184

Benzimidazole resistance in helminths: From problem to diagnosis.

Luis Fernando Viana Furtado1, Ana Cristina Passos de Paiva Bello1, Élida Mara Leite Rabelo2.   

Abstract

Helminth parasites cause significant morbidity and mortality in endemic countries. Given the severity of symptoms that helminths may elicit in the host, intervention with prophylactic and therapeutic measures is imperative. Treatment with benzimidazoles is the most widely used means of combatting these parasites. However, widespread use of these drugs can select for drug-resistant parasite strains. In this review, we approach the problem of benzimidazole resistance in helminths in both humans and animals, focusing on the properties of the drug, the molecular mechanisms of drug resistance and how resistance is diagnosed.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Benzimidazole; Drug resistance; Mass drug administration; Polymorphisms; β-tubulin

Mesh：

Substances：

Year:  2016        PMID： 27338184     DOI： 10.1016/j.actatropica.2016.06.021

Source DB:  PubMed          Journal:  Acta Trop        ISSN： 0001-706X            Impact factor:   3.112


  22 in total

1.  Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism.

Authors:  Luis Fernando Viana Furtado; Pedro Henrique Nascimento de Aguiar; Luciana Werneck Zuccherato; Talita Tatiana Guimarães Teixeira; William Pereira Alves; Vivian Jordania da Silva; Robin B Gasser; Élida Mara Leite Rabelo
Journal:  Parasitol Res       Date:  2019-01-29       Impact factor: 2.289

2.  Detection of Benzimidazole Resistance-Associated Single-Nucleotide Polymorphisms in the Beta-Tubulin Gene in Trichuris trichiura from Brazilian Populations.

Authors:  Valéria Nayara Gomes Mendes de Oliveira; Luciana Werneck Zuccherato; Talita Rodrigues Dos Santos; Élida Mara Leite Rabelo; Luis Fernando Viana Furtado
Journal:  Am J Trop Med Hyg       Date:  2022-07-25       Impact factor: 3.707

3.  Fenbendazole Controls In Vitro Growth, Virulence Potential, and Animal Infection in the Cryptococcus Model.

Authors:  Haroldo C de Oliveira; Luna S Joffe; Karina S Simon; Rafael F Castelli; Flavia C G Reis; Arielle M Bryan; Beatriz S Borges; Lia C Soares Medeiros; Anamelia L Bocca; Maurizio Del Poeta; Marcio L Rodrigues
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191

4.  Evidence for the agricultural origin of resistance to multiple antimicrobials in Aspergillus fumigatus, a fungal pathogen of humans.

Authors:  S Earl Kang; Leilani G Sumabat; Tina Melie; Brandon Mangum; Michelle Momany; Marin T Brewer
Journal:  G3 (Bethesda)       Date:  2022-02-04       Impact factor: 3.542

5.  Comparative genomics of the major parasitic worms.

Authors: 
Journal:  Nat Genet       Date:  2018-11-05       Impact factor: 38.330

6.  Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol.

Authors:  Kristjana Hrönn Ásbjörnsdóttir; Sitara S Rao Ajjampur; Roy M Anderson; Robin Bailey; Iain Gardiner; Katherine E Halliday; Moudachirou Ibikounle; Khumbo Kalua; Gagandeep Kang; D Timothy J Littlewood; Adrian J F Luty; Arianna Rubin Means; William Oswald; Rachel L Pullan; Rajiv Sarkar; Fabian Schär; Adam Szpiro; James E Truscott; Marleen Werkman; Elodie Yard; Judd L Walson
Journal:  PLoS Negl Trop Dis       Date:  2018-01-18

7.  Fasciola hepatica infection in water buffalo Bubalus bubalis in three provinces of the Nile Delta, Egypt: a cross-sectional study.

Authors:  Abdelgawad Salah El-Tahawy; Nigel Kwan; Katsuaki Sugiura
Journal:  J Vet Med Sci       Date:  2017-11-20       Impact factor: 1.267

8.  Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique.

Authors:  Xianting Ding; Zach Njus; Taejoon Kong; Wenqiong Su; Chih-Ming Ho; Santosh Pandey
Journal:  Sci Adv       Date:  2017-10-04       Impact factor: 14.136

9.  Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles.

Authors:  Steffen R Hahnel; Stefan Zdraljevic; Briana C Rodriguez; Yuehui Zhao; Patrick T McGrath; Erik C Andersen
Journal:  PLoS Pathog       Date:  2018-10-29       Impact factor: 6.823

10.  PCR-RFLP screening of polymorphisms associated with benzimidazole resistance in Necator americanus and Ascaris lumbricoides from different geographical regions in Brazil.

Authors:  Luciana Werneck Zuccherato; Luis Fernando Furtado; Celi da Silva Medeiros; Carina da Silva Pinheiro; Élida M Rabelo
Journal:  PLoS Negl Trop Dis       Date:  2018-09-17
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