Literature DB >> 27338106

Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis.

Shobha M Swamy1, Namakkal S Rajasekaran2, Victor J Thannickal3.   

Abstract

Aging and age-related diseases have been associated with elevated oxidative stress, which may be related to increased production of reactive species and/or a deficiency in antioxidant defenses. The nuclear factor-erythroid-2-related factor 2 (Nrf2)-mediated antioxidant response pathway maintains cellular reduction-oxidation homeostasis by inducing the transcription of an array of cytoprotective genes. However, there is evidence of impaired Nrf2 response in aging contributing to age-related fibrotic diseases. Herein, we review mechanisms for the dysregulation of Nrf2 signaling in aging. This understanding will pave the way for the design of novel therapeutic strategies that restore Nrf2 signaling to reestablish cellular homeostasis in aging and age-related fibrotic diseases.
Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27338106      PMCID： PMC4929397          DOI： 10.1016/j.ajpath.2016.02.022

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  135 in total

1.  Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts.

Authors:  I K Lim; K Won Hong; I H Kwak; G Yoon; S C Park
Journal:  Mech Ageing Dev       Date:  2000-11-15       Impact factor: 5.432

Review 2.  Myofibroblasts and mechano-regulation of connective tissue remodelling.

Authors:  James J Tomasek; Giulio Gabbiani; Boris Hinz; Christine Chaponnier; Robert A Brown
Journal:  Nat Rev Mol Cell Biol       Date:  2002-05       Impact factor: 94.444

3.  A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

Authors:  Alexandria Lau; Xiao-Jun Wang; Fei Zhao; Nicole F Villeneuve; Tongde Wu; Tao Jiang; Zheng Sun; Eileen White; Donna D Zhang
Journal:  Mol Cell Biol       Date:  2010-04-26       Impact factor: 4.272

4.  Incidence and prevalence of idiopathic pulmonary fibrosis.

Authors:  Ganesh Raghu; Derek Weycker; John Edelsberg; Williamson Z Bradford; Gerry Oster
Journal:  Am J Respir Crit Care Med       Date:  2006-06-29       Impact factor: 21.405

5.  Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle.

Authors:  M M Facchinetti; A R de Boland
Journal:  Cell Signal       Date:  1999-01       Impact factor: 4.315

6.  Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells.

Authors:  Naoya Miyamoto; Hiroto Izumi; Rie Miyamoto; Han Bin; Hiroyuki Kondo; Akihiko Tawara; Yasuyuki Sasaguri; Kimitoshi Kohno
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-03-02       Impact factor: 4.799

7.  The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic.

Authors:  Maria A O'Connell; John D Hayes
Journal:  Biochem Soc Trans       Date:  2015-08-03       Impact factor: 5.407

8.  Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Authors:  Collin Y Ewald; Jess N Landis; Jess Porter Abate; Coleen T Murphy; T Keith Blackwell
Journal:  Nature       Date:  2014-12-15       Impact factor: 49.962

9.  Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

Authors:  Kira M Holmström; Liam Baird; Ying Zhang; Iain Hargreaves; Annapurna Chalasani; John M Land; Lee Stanyer; Masayuki Yamamoto; Albena T Dinkova-Kostova; Andrey Y Abramov
Journal:  Biol Open       Date:  2013-06-20       Impact factor: 2.422

10.  Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

Authors:  Brian N Chorley; Michelle R Campbell; Xuting Wang; Mehmet Karaca; Deepa Sambandan; Fatu Bangura; Peng Xue; Jingbo Pi; Steven R Kleeberger; Douglas A Bell
Journal:  Nucleic Acids Res       Date:  2012-05-11       Impact factor: 16.971
View more
  19 in total

Review 1.  Reactive oxygen species as signaling molecules in the development of lung fibrosis.

Authors:  Francisco J Gonzalez-Gonzalez; Navdeep S Chandel; Manu Jain; G R Scott Budinger
Journal:  Transl Res       Date:  2017-10-10       Impact factor: 7.012

2.  Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction.

Authors:  Victor J Thannickal
Journal:  Methods Mol Biol       Date:  2021

Review 3.  Redox Imbalance in Intestinal Fibrosis: Beware of the TGFβ-1, ROS, and Nrf2 Connection.

Authors:  Giovanni Latella
Journal:  Dig Dis Sci       Date:  2018-02       Impact factor: 3.199

4.  ENERGY SENSING PATHWAYS IN AGING AND CHRONIC LUNG DISEASE.

Authors:  Victor J Thannickal
Journal:  Trans Am Clin Climatol Assoc       Date:  2020

5.  Concise Commentary: Is Nrf2 a Master Regulator of Intestinal Fibrosis?

Authors:  Giovanni Latella
Journal:  Dig Dis Sci       Date:  2018-02       Impact factor: 3.199

6.  Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.

Authors:  Geri Traver; Stacey Mont; David Gius; William E Lawson; George X Ding; Konjeti R Sekhar; Michael L Freeman
Journal:  Free Radic Biol Med       Date:  2017-09-01       Impact factor: 7.376

7.  Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria.

Authors:  Carmen Veith; Agnes W Boots; Musa Idris; Frederik-Jan van Schooten; Albert van der Vliet
Journal:  Antioxid Redox Signal       Date:  2019-04-05       Impact factor: 8.401

Review 8.  Pulmonary Innate Immune Dysfunction in Human Immunodeficiency Virus.

Authors:  Bashar S Staitieh; Eduardo E Egea; David M Guidot
Journal:  Am J Respir Cell Mol Biol       Date:  2017-05       Impact factor: 6.914

9.  Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative.

Authors:  Jun Wei; Hongyan Zhu; Gabriel Lord; Mitra Bhattachayya; Brielle M Jones; Graham Allaway; Shyam S Biswal; Benjamin Korman; Roberta G Marangoni; Warren G Tourtellotte; John Varga
Journal:  Transl Res       Date:  2016-12-09       Impact factor: 7.012

10.  α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells.

Authors:  Liduo Yue; Yanbei Ren; Qingxi Yue; Zhou Ding; Kai Wang; Tiansheng Zheng; Guojie Chen; Xiangyun Chen; Ming Li; Lihong Fan
Journal:  Oxid Med Cell Longev       Date:  2021-06-04       Impact factor: 6.543
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.